Mediterranean diet decreases the initiation of use of vitamin K epoxide reductase inhibitors and their associated cardiovascular risk: a randomized controlled trial
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Autor/a
Castro-Barquero, Sara
Ribó-Coll, Margarita
Lassale, Camille
Tresserra-Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Martínez-González, Miguel Ángel, 1957-
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez-Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol Sala, Miguel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Basterra-Gortari, Francisco Javier
Portolés, Olga
Babio, Nancy
Cofán Pujol, Montserrat
Ros Rahola, Emilio
Estruch Riba, Ramon
Hernáez, Álvaro
Otros/as autores/as
Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
Fecha de publicación
2020-12-19Resumen
Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of
the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs
(cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older
population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
Tipo de documento
Artículo
Versión publicada
Lengua
English
Materias (CDU)
613 - Higiene en general. Higiene y salud personal
616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares
Palabras clave
Dieta mediterrània
Sistema cardiovascular -- Malalties -- Prevenció
Vitamines K
Medicaments antifibrinolítics
Páginas
14 p.
Publicado por
MDPI
Publicado en
Nutrients, 2020, no. 12: 3895
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0019
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0028
info:eu-repo/grantAgreement/MINECO/ISCIII/CD17/00122
info:eu-repo/grantAgreement/MINECO/ISCIII/PIE14/00045_INFLAMES
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 BP 00021
info:eu-repo/grantAgreement/MCIU/PN I+D+i/FPU17/00785
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