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Browsing by Author "Hernáez, Álvaro"

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    • A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function: a substudy of the PREDIMED-Plus randomized controlled trial 

      Sanllorente Melenchon, Albert; Soria Florido, María Trinidad; Castañer, Olga; Lassale, Camille; Salas Salvadó, Jordi; Martínez-González, Miguel Ángel; Subirana, Isaac; Ros Rahola, Emilio; Corella Piquer, Dolores; Estruch Riba, Ramon; Tinahones Madueño, Francisco J.; Hernáez, Álvaro; Fitó Colomer, Montserrat (The American Journal of Clinical Nutrition, 2021, 114(5): 1666-1674, 2021-11)
      Background Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. ...

    • Adherence to a Mediterranean diet and leisure-time physical activity are associated with reduced initiation of antidepressant, anxiolytic, antipsychotic and antiseizure drug use in older adults: a cohort study 

      Hernández Hernández, Marta; Fornara, Eleonora; Lassale, Camille; Castañer Niño, Olga; Estruch Riba, Ramon; Ros, Emilio; Martínez-González, Miguel Ángel; Corella Piquer, Dolores; Babio, Nancy; Lapetra, José; Gómez-Gracia, Enrique; Arós, Fernando; Fiol, Miquel; Serra Majem, Lluís; Riera-Mestre, Antoni; Gea, Alfredo; Ortega Azorín, Carolina; Díaz López, Andrés; Fitó Colomer, Montserrat; Hernáez, Álvaro (Age and ageing, 2025, 54(4): afaf088, 2025-04)
      Background We explored how adherence to the Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) impact psychoactive medication use in older adults. Methods We assessed the ...

    • Association between different diet quality scores and depression risk: the REGICOR population-based cohort study 

      Lugon, Gabriela; Hernáez, Álvaro; Jacka, Felice; Marrugat, Jaume; Ramos , Rafel; Garre-Olmo, Josep; Elosua Llanos, Roberto; Lassale, Camille (European Journal of Nutrition, 2024, 63: 2885-2895, 2024-08)
      Background Our aim was to determine the association between diet quality and depression incidence in the population-based REGICOR cohort study, Catalonia, Spain. Methods Prospective observational ...

    • Association between lifestyle and hypertriglyceridemic waist phenotype in the PREDIMED-Plus Study 

      Fernández-García, José Carlos; Muñoz-Garach, Araceli; Martínez-González, Miguel Ángel, 1957-; Salas Salvadó, Jordi; Corella Piquer, Dolores; Hernáez, Álvaro; Romaguera, Dora; Vioque, Jesús; Alonso Gómez, Ángel M.; Wärnberg, Julia; Martínez, José Alfredo; Serra Majem, Lluís; Estruch Riba, Ramon; Lapetra, José; Pintó Sala, Xavier; Tur, Josep A.; Garcia-Rios, Antonio; García-Molina, Laura; Gaforio, Jose J; Matía Martín, Pilar; Daimiel, Lidia; Martín Sánchez, Vicente; Vidal, Josep; Prieto, Lucia; Ros Rahola, Emilio; Goñi, Nuria; Babio, Nancy; Ortega-Azorin, Carolina; Castañer, Olga; Konieczna, Jadwiga; Notario Barandiaran, Leyre; Vaquero Luna, Jessica; Benavente Marín, Juan Carlos; Zulet, M. Angeles; Sanchez Villegas, Almudena; Sacanella Meseguer, Emilio; Gómez Huelgas, Ricardo; Miró-Moriano, Leticia; Gimenez-Gracia, Mariano; Julibert, Alicia; Razquin, Cristina; Basora, Josep; Portolés, Olga; Goday, Alberto; Galmés-Panadés, Aina M.; López-García, Carmen M.; Moreno-Rodriguez, Anai; Toledo, Estefanía; Díaz López, Andrés; Fitó Colomer, Montserrat; Tinahones Madueño, Francisco J.; Bernal-López, M. Rosa (Obesity, 2020, 28(3): 537-543, 2020-02)
      Objective The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at ...

    • Association of physical activity with high-density lipoprotein functionality in a population-based cohort: the REGICOR study 

      Viadas, Raúl; Toloba, Andrea; Fernández, Isabel; Sayols Baixeras, Sergi; Hernáez, Álvaro; Schroeder, Helmut; Degano, Irene R.; Lassale, Camille; Marrugat, Jaume; Elosua Llanos, Roberto (Revista española de cardiología, 2023, 76(2): 86-93, 2023-02)
      Introduction and objectives To determine the dose-response association between current and past leisure-time physical activity (LTPA), total and at different intensities, and high-density lipoprotein ...

    • Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: The UK Biobank cohort study 

      Lassale, Camille; Hamer, Mark; Hernáez, Álvaro; Gale, Catharine R.; Batty, G. David (Preventive Medicine Reports, 2021, 23: 101461, 2021-06)
      There is growing evidence of, and biological plausibility for, elevated levels of high-density lipoprotein cholesterol (HDL-C) being related to lower rates of respiratory disease. We tested whether ...

    • Blood DNA methylation signature of diet quality and association with cardiometabolic traits 

      Domínguez-Barragán, Jorge; Fernández Sanlés, Alba; Hernáez, Álvaro; Llauradó-Pont, Joana; Marrugat, Jaume; Robinson, Oliver; Tzoulaki, Ioanna; Elosua Llanos, Roberto; Lassale, Camille (European Journal of Preventive Cardiology, 2024, 31, 191-202, 2023-10)
      Aims Diet quality might influence cardiometabolic health through epigenetic changes, but this has been little investigated in adults. Our aims were to identify cytosine–phosphate–guanine (CpG) dinucleotides ...

    • Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study 

      Hernáez, Álvaro; Rogne, Tormod; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Page, Christian Magnus; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Human Reproduction, 2021, 36(12), 3141-3151, 2021-10)
      STUDY QUESTION What is the association between BMI and subfertility? SUMMARY ANSWER We observed a J-shaped relationship between BMI and subfertility in both sexes, when using both a standard ...

    • Breakfast energy intake and dietary quality and trajectories of cardiometabolic risk factors in older adults 

      Pérez-Vega, Karla Alejandra; Lassale, Camille; Zomeño, M. Dolores; Castañer, Olga; Salas Salvadó, Jordi; Basterra-Gortari, Francisco Javier; Corella Piquer, Dolores; Estruch Riba, Ramon; Ros Rahola, Emilio; Tinahones Madueño, Francisco J.; Blanchart, Gemma; Malcampo, Mireia; Muñoz Aguayo, Daniel; Schröder, Helmut; Fitó Colomer, Montserrat; Hernáez, Álvaro (The Journal of nutrition, health and aging, 2024, 28(12): 100406, 2024-12)
      Objectives Not skipping breakfast is associated with a better overall diet quality and lower cardiometabolic risk. However, the impact of calorie intake and dietary quality of breakfast on cardiovascular ...

    • Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus 

      Almanza Aguilera, Enrique; Hernáez, Álvaro; Corella Piquer, Dolores; Sanllorente Melenchon, Albert; Ros Rahola, Emilio; Portolés, Olga; Valussi, Julieta; Estruch Riba, Ramon; Coltell, Oscar; Subirana, Isaac; Canudas i Puig, Sílvia; Razquin, Cristina; Blanchart, Gemma; Nonell, Lara; Fitó Colomer, Montserrat; Castañer, Olga (Journal of clinical medicine, 2020, vol. 10, núm. 1, 85, 2020-12-29)
      We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based ...

    • Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study 

      Skåra, Karoline Hansen; Hernáez, Álvaro; Næss, Øyvind; Fraser, Abigail; Lawlor, Deborah A.; Burgess, Stephen; Brumpton, Ben; Magnus, Maria Christine (Human Reproduction Open, 2024, 2024 (3), hoae033, 2024-05)
      STUDY QUESTION Are cardiovascular disease (CVD) risk factors causally associated with higher risk of infertility among women and men? SUMMARY ANSWER We found evidence to support a causal relationship ...

    • Emotional eating and cognitive restraint mediate the association between sleep quality and BMI in young adults 

      Zerón-Rugerio, María Fernanda; Hernáez, Álvaro; Cambras, Trinitat; Izquierdo Pulido, María (Appetite, 2022, 170: 105899, 2022-03)
      This cross-sectional study was designed to investigate whether diet quality and eating behaviors could mediate the association between sleep quality and body mass index (BMI) in young adults. For all ...

    • Energy balance and risk of mortality in Spanish older adults 

      Lassale, Camille; Hernáez, Álvaro; Toledo, Estefanía; Castañer, Olga; Sorlí, José V.; Salas Salvadó, Jordi; Estruch Riba, Ramon; Ros Rahola, Emilio; Alonso Gómez, Ángel M.; Lapetra, José; Cueto, Raquel; Fiol, Miquel; Serra Majem, Lluís; Pintó Sala, Xavier; Gea, Alfredo; Corella Piquer, Dolores; Babio, Nancy; Fitó Colomer, Montserrat; Schröder, Helmut (Nutrients, 2021, 13(5): 1545, 2021-05)
      Clinical data on the direct health effects of energy deficit or surplus beyond its impact on body weight are scarce. We aimed to assess the association with all-cause, cardiovascular and cancer mortality ...

    • Exceso de peso en España: situación actual, proyecciones para 2030 y sobrecoste directo estimado para el Sistema Nacional de Salud 

      Hernáez, Álvaro; Zomeño, M. Dolores; Degano, Irene R.; Pérez Fernández, Sílvia; Goday, Alberto; Vila, Joan; Civeira, Fernando; Moure, Ricardo; Marrugat, Jaume (Revista española de cardiología, 2019, 72(11): 916-924, 2019-11)
      Introducción y objetivos El exceso de peso potencia algunas enfermedades crónicas y reduce la calidad de vida, y su prevalencia crece en todo el mundo. El objetivo es estimar la evolución del exceso ...

    • Fruit and vegetable consumption is inversely associated with plasma saturated fatty acids at baseline in Predimed Plus Trial 

      Domínguez-López, Inés; Marhuenda-Muñoz, María; Tresserra-Rimbau, Anna; Hernáez, Álvaro; Moreno, Juan José; Martínez-González, Miguel Ángel; Salas Salvadó, Jordi; Corella Piquer, Dolores; Fitó Colomer, Montserrat; Martínez, José Alfredo; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Bernal-López, M. Rosa; Lapetra, José; Serra Majem, Lluís; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martín Sánchez, Vicente; Pintó Sala, Xavier; Delgado-Rodríguez, Miguel; Matía Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Serra-Mir, Mercè; Vázquez Ruiz, Zenaida; Nishi, Stephanie K.; Sorli, Jose V.; Castañer, Olga; Abete, Itziar; Vaquero Luna, Jessica; Carabaño-Moral, Rosa; Asencio, Alberto; Prohens, Lara; Garcia-Rios, Antonio; Casas, Rosa; Gómez-Pérez, Ana Maria; Santos Lozano, José Manuel; Razquin, Cristina; Martínez, María Ángeles; Saiz, Carmen; Robledo-Pastor, Vanesa; Zulet, M. Angeles; Salaverria, Itziar; Eguaras, Sonia; Babio, Nancy; Malcampo, Mireia; Ros Rahola, Emilio; Estruch Riba, Ramon; López-Sabater, Maria Carmen; Lamuela Raventós, Rosa Ma. (Molecular Nutrition and Food Research, 2021, 65(17): 2100363, 2021-09)
      Scope Plasma fatty acids (FAs) are associated with the development of cardiovascular diseases and metabolic syndrome. The aim of our study is to assess the relationship between fruit and vegetable (F&V) ...

    • High fruit and vegetable consumption and moderate fat intake are associated with higher carotenoid concentration in human plasma 

      Marhuenda-Muñoz, María; Rinaldi de Alvarenga, José Fernando; Hernáez, Álvaro; Tresserra-Rimbau, Anna; Martínez-González, Miguel Ángel; Salas Salvadó, Jordi; Corella Piquer, Dolores; Malcampo, Mireia; Alfredo Martínez, J.; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch Riba, Ramon; Tinahones Madueño, Francisco J.; Lapetra, José; Serra Majem, Lluís; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martín Sánchez, Vicente; Pintó Sala, Xavier; Delgado-Rodríguez, Miguel; Matía Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros Rahola, Emilio; Serra-Mir, Mercè; Vázquez Ruiz, Zenaida; Nishi, Stephanie K.; Sorlí, José V.; Zomeño, M. Dolores; Zulet, M. Angeles; Vaquero Luna, Jessica; Carabaño-Moral, Rosa; Notario Barandiaran, Leyre; Morey, M.; Garcia-Rios, Antonio; Gómez-Pérez, Ana Maria; Santos Lozano, José Manuel; Buil Cosiales, Pilar; Basora, Josep; Portolés, Olga; Schröder, Helmut; Abete, Itziar; Salaverria, Itziar; Toledo, Estefanía; Babio, Nancy; Fitó Colomer, Montserrat; Martínez-Huélamo, Miriam; Lamuela Raventós, Rosa Ma. (Antioxidants, 2021, 10(3): 473, 2021-03)
      Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase ...

    • High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study 

      Prats Uribe, Albert; Sayols Baixeras, Sergi; Fernández Sanlés, Alba; Subirana, Isaac; Carreras-Torres, Robert; Vilahur, Gemma; Civeira, Fernando; Marrugat, Jaume; Fitó Colomer, Montserrat; Hernáez, Álvaro; Elosua Llanos, Roberto (Metabolism Clinical and Experimental, 2020, 112: 154351, 2020-09)
      Background To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods We designed a two-sample ...

    • Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study 

      Hernáez, Álvaro; Lee, Yunsung; Page, Christian Magnus; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Magnus, Per; Njølstad, Pål R.; Andreassen, Ole A.; Corfield, Elizabeth C.; Havdahl, Alexandra; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Human Reproduction, 2024, 39(2), 436-441, 2023-11)
      STUDY QUESTION Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, ...

    • Increased consumption of virgin olive oil, nuts, legumes, whole grains, and fish promotes HDL functions in humans 

      Hernáez, Álvaro; Sanllorente Melenchon, Albert; Castañer, Olga; Martínez-González, Miguel Ángel, 1957-; Ros Rahola, Emilio; Pintó Sala, Xavier; Estruch Riba, Ramon; Salas Salvadó, Jordi; Corella Piquer, Dolores; Alonso Gómez, Ángel M.; Serra Majem, Lluís; Fiol, Miquel; Lapetra, José; Gómez-Gracia, Enrique; de la Torre, Rafael; Lamuela Raventós, Rosa Ma.; Fitó Colomer, Montserrat (Molecular nutrition and food research, 2019, 63(6): 1800847, 2019-01)
      Scope To evaluate whether increases in the consumption of cardioprotective food groups (virgin olive oil, nuts, fruits/vegetables, legumes, whole grains, fish, and wine) are associated with improvements ...

    • Mediterranean diet and antihypertensive drug use: a randomized controlled trial 

      Ribó-Coll, Margarita; Lassale, Camille; Sacanella Meseguer, Emilio; Ros Rahola, Emilio; Toledo, Estefanía; Sorlí, José V.; Babio, Nancy; Lapetra, José; Gómez-Gracia, Enrique; Alonso Gómez, Ángel M.; Fiol, Miquel; Serra Majem, Lluís; Pintó Sala, Xavier; Castañer, Olga; Díez Espino, Javier; González, José I.; Becerra-Tomás, Nerea; Cofán Pujol, Montserrat; Díaz López, Andrés; Estruch Riba, Ramon; Hernáez, Álvaro (Journal of hypertension, 2021, 39(6): 1230-1237, 2021-06)
      Objective: To examine in older individuals at high cardiovascular risk whether following a Mediterranean diet decreased the necessity of antihypertensive drugs and modulated their associated cardiovascular ...