Blood DNA methylation signature of diet quality and association with cardiometabolic traits
Author
Publication date
2023-10Abstract
Aims
Diet quality might influence cardiometabolic health through epigenetic changes, but this has been little investigated in adults. Our aims were to identify cytosine–phosphate–guanine (CpG) dinucleotides associated with diet quality by conducting an epigenome-wide association study (EWAS) based on blood DNA methylation (DNAm) and to assess how diet-related CpGs associate with inherited susceptibility to cardiometabolic traits: body mass index (BMI), systolic blood pressure (SBP), triglycerides, type 2 diabetes (T2D), and coronary heart disease (CHD).
Methods and results
Meta-EWAS including 5274 participants in four cohorts from Spain, the USA, and the UK. We derived three dietary scores (exposures) to measure adherence to a Mediterranean diet, to a healthy plant-based diet, and to the Dietary Approaches to Stop Hypertension. Blood DNAm (outcome) was assessed with the Infinium arrays Human Methylation 450K BeadChip and MethylationEPIC BeadChip. For each diet score, we performed linear EWAS adjusted for age, sex, blood cells, smoking and technical variables, and BMI in a second set of models. We also conducted Mendelian randomization analyses to assess the potential causal relationship between diet-related CpGs and cardiometabolic traits. We found 18 differentially methylated CpGs associated with dietary scores (P < 1.08 × 10−7; Bonferroni correction), of which 12 were previously associated with cardiometabolic traits. Enrichment analysis revealed overrepresentation of diet-associated genes in pathways involved in inflammation and cardiovascular disease. Mendelian randomization analyses suggested that genetically determined methylation levels corresponding to lower diet quality at cg02079413 (SNORA54), cg02107842 (MAST4), and cg23761815 (SLC29A3) were causally associated with higher BMI and at cg05399785 (WDR8) with greater SBP, and methylation levels associated with higher diet quality at cg00711496 (PRMT1) with lower BMI, T2D risk, and CHD risk and at cg0557921 (AHRR) with lower CHD risk.
Conclusion
Diet quality in adults was related to differential methylation in blood at 18 CpGs, some of which related to cardiometabolic health.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
613 - Hygiene generally. Personal health and hygiene
616.1 - Pathology of the circulatory system, blood vessels. Cardiovascular complaints
Keywords
Metilació
ADN
Dieta
Qualitat de la dieta
Sistema cardiovascular -- Malalties
Epidemiologia
Nutrició
Pages
12 p.
Publisher
Oxford University Press
Is part of
European Journal of Preventive Cardiology, 2024, 31, 191-202
Grant agreement number
info:eu-repo/grantAgreement/La Caixa/ID 100010434
info:eu-repo/grantAgreement/H2020/MSC/Grant agreement 847 648
info:eu-repo/grantAgreement/MINECO/ISCIII i FEDER/FIS PI12/00232
info:eu-repo/grantAgreement/MINECO/ISCIII i FEDER/FIS PI15/00051
info:eu-repo/grantAgreement/SUR del DEC/SGR/PERIS SLT002/16/00088
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017SGR222
info:eu-repo/grantAgreement/British Heart Foundation/AA/18/1/34219
info:eu-repo/grantAgreement/MRC/MC_UU_00011/6
info:eu-repo/grantAgreement/UKRI/MR/S03532X/1
info:eu-repo/grantAgreement/NHLBI i BU/N01-HC-25195
info:eu-repo/grantAgreement/NHLBI i BU/HHSN268201500001I
info:eu-repo/grantAgreement/NHLBI/N01WH22110
info:eu-repo/grantAgreement/NHLBI/24152
info:eu-repo/grantAgreement/NHLBI/32100-2
info:eu-repo/grantAgreement/NHLBI/32105-6
info:eu-repo/grantAgreement/NHLBI/32108-9
info:eu-repo/grantAgreement/NHLBI/32111-13
info:eu-repo/grantAgreement/NHLBI/32115
info:eu-repo/grantAgreement/NHLBI/32115
info:eu-repo/grantAgreement/NHLBI/32118-32119
info:eu-repo/grantAgreement/NHLBI/32122
info:eu-repo/grantAgreement/NHLBI/42107-26
info:eu-repo/grantAgreement/NHLBI/42129-32
info:eu-repo/grantAgreement/NHLBI/44221
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Rights
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/