Visualitzant Articles publicats en revistes per autor/a "Nonell, Santi"

Ara mostrant els elements 1-20 de 26

    • A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation 

      Nonell, Santi; Agut Bonsfills, Montserrat; Ruiz González, Rubén; Reddi, Elena (International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)
      Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ...

    • An Ultra-Long-Lived Triplet Excited State in Water at Room Temperature: Insights on the Molecular Design of Tridecafullerenes 

      Ramos-Soriano, Javier; Pérez-Sánchez, Alfonso; Ramírez-Barroso, Sergio; Beatriz, Illescas; AZMANI, KHALID; Rodriguez-Fortea, Antonio; Poblet, Josep M.; Hally, Cormac Elias; Nonell, Santi; García-Fresnadillo, David; Rojo, Javier; Martín, Nazario; Nonell (Angewandte Chemie International Edition, 2021-05-13)
      Suitably engineered molecular systems exhibiting triplet excited states with very long lifetimes are important for high-end applications in nonlinear optics, photocatalysis, or biomedicine. We report ...

    • Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer 

      Nonell, Santi; Juarranz, Ángeles; De la Torre, Gema; Torres, Tomás; Revuelta-Maza, Miguel Á.; Mascaraque, Marta; González-Jiménez, Patricia; González-Camuñas, Arturo (Molecules. Vol.25, n.1 (2020), 213, 2020-01)
      We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ...

    • Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy 

      Nonell, Santi; Ruiz González, Rubén; Torra, Joaquim; Rodríguez-Pulido, Alberto; Cortajarena, Aitziber L.; Flors, Cristina (Chemical Communications. Vol.52, n.54 (2016), p.8405-8408, 2016-06)
      Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the photostability of miniSOG mutants and their ability to photooxidize ...

    • Bactericidal effect of photodynamic therapy, alone or in combination with mupirocin or linezolid, on Staphylococcus aureus 

      Nonell, Santi; Pérez-Laguna, Vanesa; Pérez-Artiaga, Luna; Lampaya-Pérez, Verónica; García-Luque, Isabel; Ballesta, Sofía; Paz-Cristobal, Manuel P.; Gilaberte, Yolanda; Rezusta, Antonio (Frontiers in Microbiology. Vol. 8 (2017), 1002, 2017-05)
      Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an ...

    • Carminic acid linked to silica nanoparticles as pigment/antioxidant bifunctional excipient for pharmaceutical emulsions 

      Nonell, Santi; Morales, Javier; Arriagada, Francisco; Ugarte, Catalina; Günther, Germán; Larraín, María Angélica; Guarnizo-Herrero, Víctor (Pharmaceutics. Vol.12, n.4 (2020), 376, 2020-04)
      The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant ...

    • Development of green/red-absorbing chromophores based on a coumarin scaffold that are useful as caging groups 

      Nonell, Santi; Gandioso, Albert; Contreras, Sara; Melnyk, Ivanna; Oliva, Javier; Velasco Castrillo, Dolores; Garcia Amorós, Jaume; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.82, n.10 (2017), p.5398-5408, 2017-05)
      We report the design, synthesis, and spectroscopic characterization of a series of push–pull chromophores based on a novel coumarin scaffold in which the carbonyl of the lactone function of the original ...

    • Effective photodynamic inactivation of 26 Escherichia coli strains with different antibiotic susceptibility profiles: a planktonic and biofilm study 

      Nonell, Santi; Agut Bonsfills, Montserrat; Gulías Borau, Òscar; McKenzie, Giselle; Bayó, Miquel (Antibiotics. Vol.9, n.3 (2020), 98, 2020-02)
      The emergence of multidrug-resistant bacteria is a growing problem and alternative therapies are being sought to effectively address this issue. The aim of this study is to assess a range of Escherichia ...

    • Heteroacoplamientos catalizados por paladio 

      Teixidó i Closa, Jordi; Sánchez García, David; Borrós i Gómez, Salvador; Nonell, Santi; Borrell Bilbao, José Ignacio; Colominas Guàrdia, Carles (Afinidad. Vol.59, n.500 (2002), p.325-336, 2002)
      Durante los diez últimos años la química del paladio se ha aplicado intensamente en síntesis orgánica debido a su versatilidad y a su gran selectividad. En esta breve revisión se muestran las características ...

    • High photostability in nonconventional coumarins with far-red/NIR emission through azetidinyl substitution 

      Nonell, Santi; Bresolí Obach, Roger; Gandioso, Albert; Palau Requena, Marta; Galindo Muñoz, Alex; Rovira, Anna; Bosch, Manel; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.83, n.19 (2018), p.11519-11531, 2018-08)
      Replacement of electron-donating N,N-dialkyl groups with three- or four-membered cyclic amines (e.g., aziridine and azetidine, respectively) has been described as a promising approach to improve some ...

    • Morin flavonoid adsorbed on mesoporous silica, a novel antioxidant nanomaterial 

      Arriagada, Francisco; Correa, Olosmira; Günther, Germán; Nonell, Santi; Mura, Francisco; Olea-Azar, Claudio; Morales, Javier (Plos One, 2016, vol.11, 2016-11-03)
      Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in ...

    • Morphology effects on singlet oxygen production and bacterial photoinactivation efficiency by different silica-protoporphyrin IX nanocomposites 

      Nonell, Santi; Planas, O.; Gulías Borau, Òscar; Agut Bonsfills, Montserrat; Zampini, G.; Marmottini, F.; Latterini, L. (RSC Advances. Vol.7, n.24 (2017), p.14422-14429, 2017-03)
      Different silica-protoporphyrin IX (PpIX) nanocomposites have been synthesized to evaluate the dependence of singlet oxygen production and bacterial inactivation efficiency on the morphology of the ...

    • Octanol-water partition coefficients of highly hydrophobic photodynamic therapy drugs: a computational study 

      Estrada Tejedor, Roger; Sabaté, Noemí; Broto Puig, Francesc; Nonell, Santi (Afinidad. Vol.70, n.564 (2013), p.250-256, 2013-10)
      Photodynamic therapy is a novel treatment for solid tumors based on the selective induction of cell death by the generation of cytotoxic reactive oxygen species within neoplastic tissues. Oxygen ...

    • On the mechanism of Candida tropicalis biofilm reduction by the combined action of naturally-occurring anthraquinones and blue light 

      Nonell, Santi; Bresolí Obach, Roger; Agut Bonsfills, Montserrat; Marioni, Juliana; Comini, Laura R.; Cabrera, José L.; Paraje, María G.; Núñez Montoya, Susana C. (PLoS ONE. Vol.12, n.7 (2017), e0181517, 2017-07)
      The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of ...

    • Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator 

      Nonell, Santi; Bresolí Obach, Roger; Font Inglès, Joan; López-Cano, Marc; Notartomaso, Serena; Scarselli, Pamela; Di Pietro, Paola; Battaglia, Giuseppe; Malhaire, Fanny; Rovira, Xavier; Catena, Juanlo; Giraldo, Jesús; Pin, Jean-Philippe; Fernández-Dueñas, Víctor; Goudet, Cyril; Nicoletti, Ferdinando; Llebaria, Amadeu; Ciruela, Francisco (eLIFE. Vol.6 (2017), e23545, 2017-04)
      Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive ...

    • Optical writing and reading with a photoactivatable carbazole 

      Nonell, Santi; Garcia Amorós, Jaume; Swaminathan, Subramani; Zhang, Yang; Raymo, Françisco M. (Physical Chemistry Chemical Physics. Vol.17, n.17 (2015), p.11140-11143, 2015-03)
      The fluorescence of a carbazole chromophore can be activated irreversibly under optical control with the photoinduced opening of an oxazine ring. In proximity to silver nanoparticles, the quantum ...

    • Photodynamic synergistic effect of pheophorbide a and doxorubicin in combined treatment against tumoral cells 

      Nonell, Santi; Bresolí Obach, Roger; Ruiz González, Rubén; Milán, Paula; Stockert, Juan Carlos; Villanueva, Angeles; Cañete, Magdalena (Cancers. Vol.9, n.2 (2017), 18, 2017-02)
      A combination of therapies to treat cancer malignancies is at the forefront of research with the aim to reduce drug doses (ultimately side effects) and diminish the possibility of resistance emergence ...

    • Photosensitizing proteins for antibacterial photodynamic inactivation 

      Nonell, Santi; Hally Garcia, Cormac Elías; Delcanale, Pietro; Viappiani, Cristiano; Abbruzzetti, Stefania (Translational Biophotonics. Vol.2, n.1-2 (2020) e201900031, 2020-05)
      We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ...

    • Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas 

      Nonell, Santi; Sánchez García, David; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Arad, Ofir; Gavaldá, Ana; Rey, Óscar; Rubio, Noemi; Cañete, Magdalena; Juarranz, Angeles; Villanueva, Angeles; Stockert, Juan C.; Díaz Jiménez, Pablo J. (Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)
      La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...

    • Singlet oxygen in antimicrobial photodynamic therapy: photosensitizer-dependent production and decay in E. coli 

      Nonell, Santi; Agut Bonsfills, Montserrat; Ragàs Amalrich, Xavier; He, Xin; Roxo-Rosa, Mónica; Rocha Gonsalves, António; Serra, Arménio C. (Molecules. Vol.18, n.3 (2013), p.2712-2725, 2013-02)
      Several families of photosensitizers are currently being scrutinized for antimicrobial photodynamic therapy applications. Differences in physical and photochemical properties can lead to different ...