A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
Author
Nonell, Santi
Agut Bonsfills, Montserrat
Ruiz González, Rubén
Reddi, Elena
Other authors
Universitat Ramon Llull. IQS
Publication date
2015-11Abstract
Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of binding
Document Type
Article
Accepted version
Language
English
Subject (CDU)
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics
Keywords
Fotosensibilització (Biologia)
Citometria de fluxe
Fotoquimioteràpia
Photodynamic therapy
Antimicrobial photoinactivation
MRSA
P. aeruginosa
Photosensitizer
Porphycenes
Flow cytometry
Singlet oxygen
Pages
15 p.
Publisher
MDPI
Is part of
International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086
Grant agreement number
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01
info:eu-repo/grantAgreement/MINECO/PN I+D/IT2009-003
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/