Morin flavonoid adsorbed on mesoporous silica, a novel antioxidant nanomaterial
Author
Arriagada, Francisco
Correa, Olosmira
Günther, Germán
Nonell, Santi
Mura, Francisco
Olea-Azar, Claudio
Morales, Javier
Other authors
Universitat Ramon Llull. IQS
Publication date
2016-11-03Abstract
Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (¹O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.
Document Type
Article
Published version
Language
English
Subject (CDU)
546 - Inorganic chemistry
Keywords
Flavonoides
Cosmètica
Compostos químics
Pages
22 p.
Publisher
PLOS (Public Library of Science)
Is part of
Plos One, 2016, vol.11
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/