Col·leccions en aquesta comunitat
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Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study
(PLoS ONE 17(6): e0267723, 2022)This study evaluates the association of anthropometric indexes and the incidence of type 2 diabetes mellitus (T2DM) after a 5-year follow-up. This analysis included 1091 middle-aged participants (57% ... -
Characterization of a Glycolipid Synthase Producing α-Galactosylceramide in Bacteroides fragilis
(International Journal of Molecular Sciences 2022, 23(22), 13975, 2022)Glycolipids are complex molecules involved in important cellular processes. Among them, the glycosphingolipid α-galactosylceramide has proven to be of interest in biomedicine for its immunostimulatory ... -
Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy
(ChemMedChem 2022, 17(13), e202100633, 2022)Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ... -
Cost behavior in e-commerce firms
(Electronic Commerce Research 2022, 23, 2101-2134, 2022)We conduct empirical research on the flexibility of operating costs of e-commerce firms. With an international sample of firms from different European countries, we find that e-commerce firms have a ... -
Current progress in bionanomaterials to modulate the epigenome
(Biomaterials Science 2022, 18, 5021-5358, 2022)Recent advances in genomics during the 1990s have made it possible to study and identify genetic and epigenetic responses of cells and tissues to various drugs and environmental factors. This has ... -
Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
(Pharmaceuticals 2022, 15(9), 1159, 2022)Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a ... -
Bioprocess Strategies for Vitamin B12 Production by Microbial Fermentation and Its Market Applications
(Bioengineering 2022, 9(8), 365, 2022)Vitamin B12 is a widely used compound in the feed and food, healthcare and medical industries that can only be produced by fermentation because of the complexity of its chemical synthesis. For this ... -
A hybrid numerical-experimental strategy for predicting mechanical response of components manufactured via FFF
(Composite Structures 298 (2022) 115998, 2022)In this paper a new methodology developed for predicting the mechanical performance of the structures additively manufactured by Fused Filament Fabrication is presented. The novelty of the approach ... -
A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein
(Antibiotics, 11(2), 2022, 282, 2022)Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques ... -
A computational drop-in assessment of hydrofluoroethers in Organic Rankine Cycles
(Energy, 254 Part B (2022), 124319, 2022)Organic Rankine Cycles (ORCs) are experiencing a growing interest due to their ability to generate electricity from residual low waste heat sources. HFC-245fa is a representative working fluid for ORC ... -
1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
(Molecules 27(7), 2022, 2237, 2022)Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which ... -
1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
(International Journal of Molecular Sciences, 23(23), 2022, 14942, 2022)Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such ... -
Automotive Electrification Challenges Shown by Real-World Driving Data and Lifecycle Assessment
(Sustainability 2022, 14(23), 15972, 2022)Electric mobility is considered a solution to reduce carbon emissions. We expanded a lifecycle assessment with data on technical limitations and driving habits (based on real-world data) in order to ... -
Bacteriophobic Zwitterionic/Dopamine Coatings for Medical Elastomers
(Advanced Materials Interfaces, 2022, 9(30), 2201152, 2022)Despite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for ... -
BBX16 mediates the repression of seedling photomorphogenesis downstream of the GUN1/GLK1 module during retrograde signalling
(New Phytologist 2022, 234(1), 93-106, 2022)Plastid-to-nucleus retrograde signalling (RS) initiated by dysfunctional chloroplasts impact photomorphogenic development. We have previously shown that the transcription factor GLK1 acts downstream of ... -
Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice
(Journal of Neurochemistry, 2022, 160(2), 218-233, 2022)N-ethyl-pentylone (NEP), also known as ‘ephylone’ and N-ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been ... -
3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs
(Frontiers in Psychiatry, 2022)The utility of classical drugs used to treat psychiatric disorders (e.g., antidepressants, anxiolytics) is often limited by issues of lack of efficacy, delayed onset of action or side effects. Psychoactive ... -
Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model
(European Cells & Materials Journal, 2021-01-07)The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely ... -
Entrapped Transient Chloroform Solvates of Bilastine
(Crystals, 2021-03-28)The knowledge about the solid forms landscape of Bilastine (BL) has been extended. The crystal structures of two anhydrous forms have been determined, and the relative thermodynamic stability among the ... -
Re-purposing tourism: engaging our radical in tourism education
(Journal of Teaching in Travel & Tourism, 2022-02-06)