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Novel grafted electrochemical interface for covalent glucose oxidase immobilization using reactive pentafluorophenyl methacrylate
(Colloids and Surfaces B: Biointerfaces, 2018-12-01)One of the most important factors for the proper functioning of enzymatic electrochemical biosensors is the enzyme immobilization strategy. In this work, glucose oxidase was covalently immobilized using ... -
Novel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleen
(Journal of Materials Chemistry B, 2023-06-14)mRNA vaccination has emerged as a prominent therapy for the future of medicine. Despite the colossal advance in this technology and worldwide efficacy proof (ca. COVID vaccines), mRNA carriers still ... -
Chloroplast engineering of the green microalgae Chlamydomonas reinhardtii for the production of HAA, the lipid moiety of rhamnolipid biosurfactants
(New Biotechnology, 2023-04-11)Hydroxyalkanoyloxyalkanoates (HAA) are lipidic surfactants with a number of potential applications, but more remarkably, they are the biosynthetic precursors of rhamnolipids (RL), which are preferred ... -
Cyclic Homo- and Heterohalogen Di-λ3-diarylhalonium Structures
(Journal of the American Chemical Society, 2023-06-13)In the context of the ever-growing interest in thecyclic diaryliodonium salts, this work presents synthetic designprinciples for a new family of structures with two hypervalenthalogens in the ring. The ... -
Advanced mass spectrometry profiling of phenolic and minerals compounds in herbal beverages
(Food Chemistry, 2023-07-01)The global pandemic of COVID-19 has led to an increased interest in herbal infusions as natural remedies since 2020. This has also heightened the need for controlling the composition of these dietary ... -
Analytical parameters of an amperometric glucose biosensor for fast analysis in food samples
(Sensors, 2017-11-14)Amperometric biosensors based on the use of glucose oxidase (GOx) are able to combine the robustness of electrochemical techniques with the specificity of biological recognition processes. However, very ... -
Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
(Scientific Reports, 2021-01-14)Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance ... -
Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna
(Science of the Total Environment, 2021-07-28)Pharmaceuticals and other emerging contaminants are continuously released into the aquatic environment, considered as ‘pseudo-persistent’ pollutants. Many compounds degrade fast in the environment, but ... -
Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1
(Computational and Structural Biotechnology Journal, 2020-11-28)Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ... -
The sequential action of MIDA9/PP2C.D1, PP2C.D2, and PP2C.D5 is necessary to form and maintain the hook after germination in the dark
(Frontiers in Plant Science, 2021-03-09)During seedling etiolation after germination in the dark, seedlings have closed cotyledons and form an apical hook to protect the meristem as they break through the soil to reach the surface. Once in ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
(Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Exploring benzylic gem-C(sp3)–boron–silicon and boron–tin centers as a synthetic platform
(Chemical Science, 2021-07-02)A stepwise build-up of multi-substituted Csp3 carbon centers is an attractive, conceptually simple, but often synthetically challenging type of disconnection. To this end, this report describes how ... -
Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
(Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety
(Environment International, 2020-11-18)Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ... -
Differential modulation of the central and peripheral monoaminergic neurochemicals by deprenyl in Zebrafish Larvae
(Toxics, 2021-05-23)Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is ... -
Extracellular vesicles and their current role in cancer immunotherapy
(Cancers, 2021-05-10)Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ... -
Analytical parameters of a novel glucose biosensor based on grafted PFM as a covalent immobilization technique
(Sensors, 2021-06-15)Bioanalytical methods, in particular electrochemical biosensors, are increasingly used in different industrial sectors due to their simplicity, low cost, and fast response. However, to be able to reliably ... -
Experimental, computational, and dimensional analysis of the mechanical performance of fused filament fabrication parts
(Polymers, 2021-05-27)Process parameters in Additive Manufacturing (AM) are key factors in the mechanical performance of 3D-printed parts. In order to study their effect, a three-zone model based on the printing pattern was ... -
Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
(Scientific Reports, 2021-09-30)In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and ... -
Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy
(Pharmaceutics, 2021-11-19)Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical transurethral resection. ...