Morphology effects on singlet oxygen production and bacterial photoinactivation efficiency by different silica-protoporphyrin IX nanocomposites
Author
Nonell, Santi
Planas, Oriol
Gulías Borau, Òscar
Agut Bonsfills, Montserrat
Zampini, G.
Marmottini, F.
Latterini, L.
Other authors
Universitat Ramon Llull. IQS
Publication date
2017-03Abstract
Different silica-protoporphyrin IX (PpIX) nanocomposites have been synthesized to evaluate the dependence of singlet oxygen production and bacterial inactivation efficiency on the morphology of the nanomaterials. Modulation of the synthetic procedure allowed obtaining silica nanoparticles with different porosity which were characterized by TEM and spectroscopic analysis after PpIX adsorption. Time-resolved phosphorescence measurements on the different nanoporous samples revealed that the porosity of the nanoparticles plays a pivotal role on the singlet oxygen production and release from the nanoparticles. Thus, apart from the expected decay of singlet oxygen outside the silica matrix, a second component has been observed for the porous materials, attributed to the decay of singlet oxygen inside the pores. The relative efficiency of singlet oxygen production resulted to be higher for the sample with the greatest pores volume. The capability of the nanocomposites to inactivate bacteria was tested in vitro on Staphylococcus aureus strain. Interestingly, the efficiency for singlet oxygen production of the nanocomposites and their bacterial inactivation efficiency followed a different trend, indicating that the relative position of the photosensitizer and the superficial properties of the particles affect the antibacterial activity of the overall system.
Document Type
Article
Published version
Language
English
Subject (CDU)
54 - Chemistry. Crystallography. Mineralogy
Keywords
Nanocompòsits (Materials)
Sílice
Fotosensibilització (Biologia)
Nanocomposites
Silica nanoparticles
Photosensitization (Biological)
Pages
8 p.
Publisher
The Royal Society of Chemistry
Is part of
RSC Advances. Vol.7, n.24 (2017), p.14422-14429
Grant agreement number
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2016 FI_B2_00100
This item appears in the following Collection(s)
Rights
© The Royal Society of Chemistry
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/