Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
Author
Publication date
2020-12-29Abstract
We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤−2.0 “downregulation”). Cancer signaling pathways were
the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
Document Type
Article
Published version
Language
English
Subject (CDU)
575 - General genetics. General cytogenetics
616 - Pathology. Clinical medicine
Pages
12 p.
Publisher
MDPI
Is part of
Journal of clinical medicine, 2020, vol. 10, núm. 1, 85
Grant agreement number
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222
info:eu-repo/grantAgreement/Fundació la Marató de TV3/201512.31
info:eu-repo/grantAgreement/MINECO/ISCIII/JR17/00022
info:eu-repo/grantAgreement/MINECO/ISCIII/Pl15/00047
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/