Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
Author
Almanza Aguilera, Enrique
Hernáez, Álvaro
Corella Piquer, Dolores
Ros Rahola, Emilio
Portolés, Olga
Valussi, Julieta
Estruch Riba, Ramon
Coltell, Oscar
Subirana Cachinero, Isaac
Canudas i Puig, Sílvia
Razquin, Cristina
Blanchart, Gemma
Nonell, Lara
Fitó Colomer, Montserrat
Castañer, Olga
Other authors
Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
Publication date
2020-12-29Abstract
We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤−2.0 “downregulation”). Cancer signaling pathways were
the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
Document Type
Article
Published version
Language
English
Subject (CDU)
575 - General genetics. General cytogenetics
616 - Pathology. Clinical medicine
Keywords
Transcripció genètica
Factors de transcripció
Diabetis
Càncer
Pages
12 p.
Publisher
MDPI
Is part of
Journal of clinical medicine, 2020, vol. 10, núm. 1, 85
Grant agreement number
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222
info:eu-repo/grantAgreement/Fundació la Marató de TV3/201512.31
info:eu-repo/grantAgreement/MINECO/ISCIII/JR17/00022
info:eu-repo/grantAgreement/MINECO/ISCIII/Pl15/00047
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/