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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorHernáez, Álvaro
dc.contributor.authorLassale, Camille
dc.contributor.authorCastro-Barquero, Sara
dc.contributor.authorRos Rahola, Emilio
dc.contributor.authorTresserra i Rimbau, Anna
dc.contributor.authorCastañer, Olga
dc.contributor.authorPintó Sala, Xavier
dc.contributor.authorVázquez Ruiz, Zenaida
dc.contributor.authorSorlí, José V.
dc.contributor.authorSalas Salvadó, Jordi
dc.contributor.authorLapetra, José
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorAlonso Gómez, Ángel M.
dc.contributor.authorFiol, Miquel
dc.contributor.authorSerra Majem, Lluís
dc.contributor.authorSacanella Meseguer, Emilio
dc.contributor.authorRazquin, Cristina
dc.contributor.authorCorella Piquer, Dolores
dc.contributor.authorGuasch-Ferré, Marta
dc.contributor.authorCofán Pujol, Montserrat
dc.contributor.authorEstruch Riba, Ramon
dc.date.accessioned2023-01-23T19:32:06Z
dc.date.accessioned2023-07-12T12:05:33Z
dc.date.available2023-01-23T19:32:06Z
dc.date.available2023-07-12T12:05:33Z
dc.date.created2021-01
dc.date.issued2021-02
dc.identifier.urihttp://hdl.handle.net/20.500.14342/761
dc.description.abstractThere is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
dc.format.extent13 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofNutrients, 2021, 13, 559cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherDieta mediterràniacat
dc.subject.otherPlaquetes sanguínies --Trastornscat
dc.subject.otherTrombocitopènia -- Prevenciócat
dc.titleMediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trialcat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc613
dc.subject.udc616.1
dc.identifier.doihttps://doi.org/10.3390/nu13020559cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0019cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0028cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CD17/00122cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PIE14/00045_INFLAMEScat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/PN I+D/FPU17/00785cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/BP/2017-BP-00021cat


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