Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
Ver/Abrir
Autor/a
Otros/as autores/as
Fecha de publicación
2021-02Resumen
There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
Tipo de documento
Artículo
Versión publicada
Lengua
Inglés
Materias (CDU)
613 - Higiene en general. Higiene y salud personal
616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares
Palabras clave
Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
Páginas
13 p.
Publicado por
MDPI
Publicado en
Nutrients, 2021, 13, 559
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0019
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0028
info:eu-repo/grantAgreement/MINECO/ISCIII/CD17/00122
info:eu-repo/grantAgreement/MINECO/ISCIII/PIE14/00045_INFLAMES
info:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222
info:eu-repo/grantAgreement/MICINN/PN I+D/FPU17/00785
info:eu-repo/grantAgreement/SUR del DEC/BP/2017-BP-00021
Este ítem aparece en la(s) siguiente(s) colección(ones)
Derechos
© L'autor/a
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by/4.0/