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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorAlmanza Aguilera, Enrique
dc.contributor.authorHernáez, Álvaro
dc.contributor.authorCorella Piquer, Dolores
dc.contributor.authorSanllorente Melenchon, Albert, 1990-
dc.contributor.authorRos Rahola, Emilio
dc.contributor.authorPortolés, Olga
dc.contributor.authorValussi, Julieta
dc.contributor.authorEstruch Riba, Ramon
dc.contributor.authorColtell, Oscar
dc.contributor.authorSubirana Cachinero, Isaac
dc.contributor.authorCanudas i Puig, Sílvia
dc.contributor.authorRazquin, Cristina
dc.contributor.authorBlanchart, Gemma
dc.contributor.authorNonell, Lara
dc.contributor.authorFitó Colomer, Montserrat
dc.contributor.authorCastañer, Olga
dc.date.accessioned2022-03-03T06:53:15Z
dc.date.accessioned2023-07-12T12:05:06Z
dc.date.available2022-03-03T06:53:15Z
dc.date.available2023-07-12T12:05:06Z
dc.date.created2020-11-19
dc.date.issued2020-12-29
dc.identifier.urihttp://hdl.handle.net/20.500.14342/727
dc.description.abstractWe aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini–Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant “upregulation” and ≤−2.0 “downregulation”). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, −log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, −log(p-value) = 2.03) and paxillin (z-score = 2.33, −log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = −2.14, −log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.eng
dc.format.extent12 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofJournal of clinical medicine, 2020, vol. 10, núm. 1, 85cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherTranscripció genèticacat
dc.subject.otherFactors de transcripciócat
dc.subject.otherDiabetiscat
dc.subject.otherCàncercat
dc.titleCancer signaling transcriptome is upregulated in type 2 diabetes mellituscat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc575
dc.subject.udc616
dc.identifier.doihttp://dx.doi.org/10.3390/jcm10010085cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundació la Marató de TV3/201512.31cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/JR17/00022cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/Pl15/00047cat


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Attribution 4.0 International
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