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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorCastro-Barquero, Sara
dc.contributor.authorRibó-Coll, Margarita
dc.contributor.authorLassale, Camille
dc.contributor.authorTresserra-Rimbau, Anna
dc.contributor.authorCastañer, Olga
dc.contributor.authorPintó Sala, Xavier
dc.contributor.authorMartínez-González, Miguel Ángel, 1957-
dc.contributor.authorSorlí, José V.
dc.contributor.authorSalas Salvadó, Jordi
dc.contributor.authorLapetra, José
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorAlonso Gómez, Ángel M.
dc.contributor.authorFiol Sala, Miguel
dc.contributor.authorSerra Majem, Lluís
dc.contributor.authorSacanella Meseguer, Emilio
dc.contributor.authorBasterra-Gortari, Francisco Javier
dc.contributor.authorPortolés, Olga
dc.contributor.authorBabio, Nancy
dc.contributor.authorCofán Pujol, Montserrat
dc.contributor.authorRos Rahola, Emilio
dc.contributor.authorEstruch Riba, Ramon
dc.contributor.authorHernáez, Álvaro
dc.date.accessioned2022-11-22T14:52:36Z
dc.date.accessioned2023-07-12T12:05:04Z
dc.date.available2022-11-22T14:52:36Z
dc.date.available2023-07-12T12:05:04Z
dc.date.created2020-11-23
dc.date.issued2020-12-19
dc.identifier.urihttp://hdl.handle.net/20.500.14342/724
dc.description.abstractOur aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.eng
dc.format.extent14 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofNutrients, 2020, no. 12: 3895cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherDieta mediterràniacat
dc.subject.otherSistema cardiovascular -- Malalties -- Prevenciócat
dc.subject.otherVitamines Kcat
dc.subject.otherMedicaments antifibrinolíticscat
dc.titleMediterranean diet decreases the initiation of use of vitamin K epoxide reductase inhibitors and their associated cardiovascular risk: a randomized controlled trialcat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc613
dc.subject.udc616.1
dc.identifier.doihttps://doi.org/10.3390/nu12123895cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0019cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CB06/03/0028cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/CD17/00122cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PIE14/00045_INFLAMEScat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 BP 00021cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIU/PN I+D+i/FPU17/00785cat


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