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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorRibó-Coll, Margarita
dc.contributor.authorLassale, Camille
dc.contributor.authorSacanella Meseguer, Emilio
dc.contributor.authorRos, Emilio
dc.contributor.authorToledo, Estefanía
dc.contributor.authorSorlí, José V.
dc.contributor.authorBabio, Nancy
dc.contributor.authorLapetra, José
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorAlonso Gómez, Ángel M.
dc.contributor.authorFiol, Miquel
dc.contributor.authorSerra Majem, Lluís
dc.contributor.authorPintó Sala, Xavier
dc.contributor.authorCastañer, Olga
dc.contributor.authorDíez Espino, Javier
dc.contributor.authorGonzález, José I.
dc.contributor.authorBecerra-Tomás, Nerea
dc.contributor.authorCofán Pujol, Montserrat
dc.contributor.authorDíaz López, Andrés
dc.contributor.authorEstruch Riba, Ramon
dc.contributor.authorHernáez, Álvaro
dc.date.accessioned2024-10-17T19:46:32Z
dc.date.available2024-10-17T19:46:32Z
dc.date.issued2021-06
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4437
dc.description.abstractObjective: To examine in older individuals at high cardiovascular risk whether following a Mediterranean diet decreased the necessity of antihypertensive drugs and modulated their associated cardiovascular risk. Methods: In the PREvención con DIeta MEDiterránea study, we assessed whether volunteers randomly allocated to an intervention with a Mediterranean diet enriched with extra-virgin olive oil or nuts (relative to a low-fat control diet) disclosed differences in the risk of: initiating antihypertensive medication in nonusers at baseline (n = 2188); and escalating therapy in participants using one, two, or three drugs at baseline (n = 2361, n = 1579, and n = 554, respectively). We also assessed whether allocation to Mediterranean diet modified the association between antihypertensive drug use and incident cardiovascular events. Results: Participants allocated to Mediterranean diet interventions were associated with lower risk of initiating antihypertensive therapy [5-year incidence rates: 47.1% in the control diet, 43.0% in MedDiets; hazard ratio = 0.84, 95% CI (0.74--0.97), in a model adjusted for age, sex, and recruitment site]. Volunteers using two drugs at baseline in the Mediterranean diet intervention enriched with extra-virgin olive oil decreased their risk of therapy escalation [5-year incidence rates: 22.9% in the control diet, 20.1% in the MedDiet; hazard ratio = 0.77, 95% CI (0.60--0.99)]. Allocation to Mediterranean diet interventions attenuated the association between antihypertensive therapy at baseline and incidence of major adverse cardiovascular events (P interaction = 0.003). Conclusion: In an older population at high cardiovascular risk, following a Mediterranean diet reduced the risk of initiating or escalating antihypertensive medication and attenuated cardiovascular risk in antihypertensive drug users.ca
dc.format.extent7 p.ca
dc.language.isoengca
dc.publisherWolters Kluwer Healthca
dc.relation.ispartofJournal of hypertension, 2021, 39(6): 1230-1237ca
dc.rights© Wolters Kluwer Health, Inc. Tots els drets reservatsca
dc.subject.otherAgent antihipertensiuca
dc.subject.otherDieta mediterràniaca
dc.subject.otherNutricióca
dc.subject.otherMedicina preventivaca
dc.subject.otherAssaigs clínicsca
dc.titleMediterranean diet and antihypertensive drug use: a randomized controlled trialca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.terms12 mesosca
dc.identifier.doihttps://doi.org/10.1097/HJH.0000000000002765ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i COFB/CB06/03/0019ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i COFB/CB06/03/0028ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i COFB/CD17/00122ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-SGR-222ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-BP-00021ca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca


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