Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
Author
Bellot, Marina
Prats, Eva
Barata, Carlos
Antolín, Albert A.
Other authors
Universitat Ramon Llull. IQS
Publication date
2023-12-14ISSN
1879-1026
Abstract
The current view is that environmental levels of nicotine and cotinine, commonly in the ng/L range, are safe for aquatic organisms. In this study, 7 days post-fertilization zebrafish embryos have been exposed for 24 h to a range of environmental concentrations of nicotine (2.0 ng/L-2.5 μg/L) and cotinine (50 pg/L–10 μg/L), as well as to a binary mixture of these emerging pollutants. Nicotine exposure led to hyperactivity, decreased vibrational startle response and increased non-associative learning. However, the more consistent effect found for both nicotine and cotinine was a significant increase in light-off visual motor response (VMR). The effect of both pollutants on this behavior occurred through a similar mode of action, as the joint effects of the binary mixture of both chemicals were consistent with the concentration addition concept predictions. The results from docking studies suggest that the effect of nicotine and cotinine on light-off VMR could be mediated by zebrafish α7 nAChR
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
504 - Threats to the environment
Keywords
Nicotine
Cotinine
Fish Larvae
Behavior
Nicotine Acetylcholine Receptor
Pages
11p.
Publisher
Elsevier
Is part of
Science of the Total Environment
Grant agreement number
info:eu-repo/grantAgreement/AEI-MCI/PID2020-113371RB-C21
info:eu-repo/grantAgreement/AEI-MCI/PID2020-113371RB-C22
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/