Browsing by Author "Raldúa, Demetrio"
Now showing items 1-16 of 16
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A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure
Bedrossiantz, Juliette; Bellot, Marina; Domínguez García, Pol; Faria, Melissa; Prats, Eva; Gómez-Canela, Cristian; López-Arnau, Raúl; Fonseca, David; Raldúa, Demetrio (Frontiers in Pharmacology, 2021-11-22)Hyperthermia is a common confounding factor for assessing the neurotoxic effects of methamphetamine (METH) in mammalian models. The development of new models of methamphetamine neurotoxicity using ... -
Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion
Faria, Melissa; Prats, Eva; Rosas Ramírez, Jonathan Ricardo; Bellot, Marina; Bedrossiantz, Juliette; Pagano, Maria; Valls, Arnau; Gómez-Canela, Cristian; Porta, Josep M; Mestres, Jordi; Garcia-Reyero, Natàlia; Faggio, Caterina; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Science of the Total Environment, 2021-06-25)Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ... -
Cardiac and neurobehavioral impairments in three phylogenetically distant aquatic model organisms exposed to environmentally relevant concentrations of boscalid
Bedrossiantz, Juliette; Goyenechea, Júlia; Prats, Eva; Gómez-Canela, Cristian; Barata, Carlos; Raldúa, Demetrio; Cachot, Jérôme (Environmental Pollution. 2024;347:123685, 2024-03-16)Boscalid (2-Chloro-N-(4′-chlorobiphenyl-2-yl) nicotinamide), a pyridine carboxamide fungicide, is an inhibitor of the complex II of the respiration chain in fungal mitochondria. As boscalid is only ... -
Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish
Mayol Cabré, Marta; Prats, Eva; Raldúa, Demetrio; Gómez-Canela, Cristian (Science of The Total Environment. 2020;745:141205, 2020-07-30)Monoaminergic neurotransmitters are the main components that regulate of a lot of processes in the vertebrate brain. There is growing interest to monitor the changes produced in these neurochemicals due ... -
Differential modulation of the central and peripheral monoaminergic neurochemicals by deprenyl in Zebrafish Larvae
Bellot, Marina; Bartolomé, Helena; Faria, Melissa; Gómez-Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-23)Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is ... -
Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae
Ricarte, Marina; Prats, Eva; Montemurro, Nicola; Bedrossiantz, Juliette; Bellot, Marina; Gómez-Canela, Cristian; Raldúa, Demetrio (Science of The Total Environment 2023, 896, 165240, 2023-10-20)N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-quinone) is a degradation product of 6PPD, an antioxidant widely used in rubber tires. 6PPD-quinone enters aquatic ecosystems through ... -
Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B
Faria, Melissa; Bellot, Marina; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Prats, Eva; Garcia-Reyero, Natàlia; Gómez-Canela, Cristian; Mestres, Jordi; Rovira, Xavier; Barata, Carlos; Gómez-Oliván, Leobardo Manuel; Llebaria, Amadeu; Raldúa, Demetrio (Journal of Hazardous Materials Volume 2022, 431,128563, 2022)The insecticide carbaryl is commonly found in indirectly exposed freshwater ecosystems at low concentrations considered safe for fish communities. In this study, we showed that after only 24 h of exposure ... -
From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
Bellot, Marina; Carrillo, Maria Paula; Bedrossiantz, Juliette; Zheng, Jiamin; Mandal, Rupasri; Wishart, David S.; Gómez-Canela, Cristian; Vila-Costa, Maria; Prats, Eva; Piña, Benjamí; Raldúa, Demetrio (Ecotoxicology and Environmental Safety, 2023-12-26)Glyphosate, a globally prevalent herbicide known for its selective inhibition of the shikimate pathway in plants, is now implicated in physiological effects on humans and animals, probably due to its ... -
Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety
Faria, Melissa; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Mayol, Marta; Heredia García, Gerardo; Bellot, Marina; Prats, Eva; Garcia-Reyero, Natàlia; Gómez-Canela, Cristian; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Environment International, 2020-11-18)Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ... -
Impact of environmentally relevant concentrations of fluoxetine on zebrafish larvae: From gene to behavior
Correia, Daniela; Bellot, Marina; Prats, Eva; Gómez-Canela, Cristian; Moro, Hugo; Raldúa, Demetrio; Domingues, Ines; Oliveira, Miguel; Faria, Melissa (Chemosphere 2023, 345, 2023-12)Fluoxetine is widely prescribed for the treatment of depressive states, acting at the level of the central nervous system, consequently affecting non-target organisms. This study aimed to investigate ... -
Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish
Correia, Daniela; Bellot, Marina; Goyenechea, Júlia; Prats, Eva; Moro, Hugo; Gómez-Canela, Cristian; Bedrossiantz, Juliette; Tagkalidou, Niki; Ferreira, Carla S.S.; Raldúa, Demetrio; Domingues, Inês; Faria, Melissa; Oliveira, Miguel (Chemosphere. 2024;355:141851, 2024-04-09)Fish have common neurotransmitter pathways with humans, exhibiting a significant degree of conservation and homology. Thus, exposure to fluoxetine makes fish potentially susceptible to biochemical and ... -
Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
Bellot, Marina; Faria, Melissa; Gómez-Canela, Cristian; Raldúa, Demetrio; Barata, Carlos (Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
Faria, Melissa; Prats, Eva; Bellot, Marina; Gómez-Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
Ricarte, Marina; Tagkalidou, Niki; Bellot, Marina; Bedrossiantz, Juliette; Prats, Eva; Gómez-Canela, Cristian; Garcia-Reyero, Natàlia; Raldúa, Demetrio (International Journal of Molecular Sciences. 2024;25(14):7688, 2024-07-13)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. ... -
Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
Bellot, Marina; Manen Freixa, Leticia; Prats, Eva; Bedrossiantz, Juliette; Barata, Carlos; Gómez-Canela, Cristian; Antolín, Albert A.; Raldúa, Demetrio (Science of the Total Environment, 2023-12-14)The current view is that environmental levels of nicotine and cotinine, commonly in the ng/L range, are safe for aquatic organisms. In this study, 7 days post-fertilization zebrafish embryos have been ... -
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
Gómez-Canela, Cristian; Faria, Melissa; Prats, Eva; Hsu, Chuan-Yu; Arick, Mark A. II; Bedrossiantz, Juliette; Orozco, Manuel; Garcia-Reyero, Natàlia; Ziv, Tamar; Ben-Lulu, Shani; Admon, Arie; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ...