Browsing Articles publicats en revistes by Author 

Browsing Articles publicats en revistes by Author "Puig de la Bellacasa Cazorla, Raimon"

Now showing items 1-9 of 9

    • 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications 

      Oliveras, Juan Marcos; Puig de la Bellacasa Cazorla, Raimon; Estrada Tejedor, Roger; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio (Pharmaceuticals 2021;14(10):1029, 2021-10-09)
      Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members ...

    • 1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications 

      Donaire-Arias, Ana; Montagut, Ana Maria; Puig de la Bellacasa Cazorla, Raimon; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio (Molecules 27(7), 2022, 2237, 2022)
      Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which ...

    • Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Puig de la Bellacasa Cazorla, Raimon; Roué, Gaël; Balsas, P.; Esteve-Arenys, A.; Roldán, J.; Jiménez, L.; Rodríguez, V.; Valero, J. G.; Chamorro-Jorganes, A.; Matas-Céspedes, A.; Moros, A.; Martínez, A.; Campo, E.; Sáez-Borderías, A.; Pérez-Galán, P.; Colomer, D. (Journal of Hematology & Oncology. Vol.10, n.80 (2017), 2017-03)
      Background Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical activity ...

    • Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity 

      Martínez-Asensio, Miquel; Sàrrias, Lluís; Gorjón de Pablo, Gema; Fernández-Serrano, Miranda; Camaló Vila, Judith; Puig de la Bellacasa Cazorla, Raimon; Teixidó i Closa, Jordi; Roué, Gaël; Borrell Bilbao, José Ignacio; Estrada Tejedor, Roger; Gibert Bosch, Albert (International Journal of Molecular Sciences. 2024;25(17):9446, 2024-08-28)
      The identification of new compounds with potential activity against CXC chemokine receptor type 4 (CXCR4) has been broadly studied, implying several chemical families, particularly AMD3100 derivatives. ...

    • Autocatalytic photoinduced oxidative dehydrogenation of pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis of C5–C6 unsaturated systems with concomitant formation of a long-lived radical 

      de Rocafiguera, Claudi; Lloveras, Vega; Vidal Gancedo, José; Teixidó i Closa, Jordi; Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Puig de la Bellacasa Cazorla, Raimon (Organic Chemistry Frontiers, 2024, 11(1), 2024-01-07)
      5,6-Dihydropyrido[2,3-d]pyrimidin-7(8H)-ones are readily accessed by a variety of methods and are a good scaffold for the development of biologically active compounds. However, they are very reluctant ...

    • Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70 

      Masip, Victor; Lirio, Ángel; Sánchez-López, Albert; Cuenca, Ana B.; Puig de la Bellacasa Cazorla, Raimon; Abrisqueta, Pau; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio; Gibert, Albert; Estrada Tejedor, Roger (Pharmaceuticals 2021;14(12):1311, 2021-12-15)
      Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. ...

    • From propenolysis to enyne metathesis: tools for expedited assembly of 4a,8a-azaboranaphthalene and extended polycycles with embedded BN 

      RULLI, FEDERICA; Sanz-Liarte, Guillem; Roca Codina, Pol; Martínez, Nina; Medina, Víctor; Puig de la Bellacasa Cazorla, Raimon; Shafir, Alexandr; Cuenca, Ana B. (Chemical Science. 2024;15(15):5674-5680, 2024-03-07)
      The synthesis of BN-containing molecules, which have an interesting isosteric relationship to their parent all-C cores, has drawn a great deal of attention as an avenue to alter and tune molecular ...

    • Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors 

      Borrell Bilbao, José Ignacio; Puig de la Bellacasa Cazorla, Raimon; Gibert Bosch, Albert; Planesas, Jesús M.; Ros Blanco, Laia; Batllori Aguilà, Xavier; Badía, Roger; Clotet i Sala, Bonaventura; Esté, José A.; Teixidó i Closa, Jordi (Organic & Biomolecular Chemistry. Vol.14, n.4 (2016), p.1455-1472, 2015-12)
      The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined ...

    • When Unsuspected Crystallinity Ruins Biological Testing in Early Discovery: A Case Study 

      de Rocafiguera, Claudi; Belsa, Blanca; Font-Bardia, Mercè; Puigjaner, Cristina; Serra Hosta, Eduard; Cuartero Albesa, Ana María; Puig de la Bellacasa Cazorla, Raimon; Borrell Bilbao, José Ignacio (Pharmaceuticals. 2024;17(3):284, 2024-02-22)
      The impact of the crystalline or amorphous structure of a solid on the solubility and pharmacokinetic properties of a drug candidate is always considered by the pharmaceutical industry during the ...