1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications
Author
Oliveras, Juan Marcos
Puig de la Bellacasa Cazorla, Raimon
Estrada Tejedor, Roger
Teixidó i Closa, Jordi
Borrell Bilbao, José Ignacio
Other authors
Universitat Ramon Llull. IQS
Publication date
2021-10-09ISSN
1424-8247
Abstract
Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members of such a family capable of providing ligands for several receptors in the body. Among such structures, 1,6-naphthyridin-2(1H)-ones (7) are a subfamily that includes more than 17,000 compounds (with a single or double bond between C3 and C4) included in more than 1000 references (most of them patents). This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, C7, and C8 of 1,6-naphthyridin-2(1H)-ones, the synthetic methods used for their synthesis (both starting from a preformed pyridine or pyridone ring), and the biomedical applications of such compounds.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
547 - Organic chemistry
Keywords
1,6-naphthyridin-2(1H)-one
substitution pattern
synthesis
biological activity
Pages
15
Publisher
MDPI
Is part of
Pharmaceuticals 2021;14(10):1029
Grant agreement number
info:eu-repo/grantAgreement/MCIU/PN I+D/RTI2018-096455-B-I00
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/