1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
Author
Donaire-Arias, Ana
Montagut, Ana Maria
Puig de la Bellacasa Cazorla, Raimon
Teixidó i Closa, Jordi
Borrell Bilbao, José Ignacio
Other authors
Universitat Ramon Llull. IQS
Publication date
2022ISSN
1420-3049
Abstract
Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
54 - Chemistry. Crystallography. Mineralogy
547 - Organic chemistry
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics
61 - Medical sciences
Keywords
1H-pyrazolo[3,4-b]pyridines
Substitution pattern
Synthesis
Biological activity
Pages
p. 36
Publisher
MDPI
Is part of
Molecules 27(7), 2022, 2237
Grant agreement number
info:eu-repo/grantAgreement/MICINN/PN I+D/RTI2018-096455-B-I00
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/