IQS: Enviaments recents
Ara mostrant els elements 241-260 de 736
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High-Compression Crash Simulations and Tests of PLA Cubes Fabricated Using Additive Manufacturing FDM with a Scaling Strategy
(Computation. 2024;12(3):40, 2024-02-23)Impacts due to drops or crashes between moving vehicles necessitate the search for energy absorption elements to prevent damage to the transported goods or individuals. To ensure safety, a given level ... -
A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions
(Chemical Space 2023, 15(26), 2023-07-14)Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially ... -
Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates
(Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ... -
Cyclic Homo- and Heterohalogen Di-λ3-diarylhalonium Structures
(Journal of the American Chemical Society 2023, 145 (25), 13796–13804, 2023-06-28)In the context of the ever-growing interest in the cyclic diaryliodonium salts, this work presents synthetic design principles for a new family of structures with two hypervalent halogens in the ring. ... -
Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae
(Science of The Total Environment 2023, 896, 165240, 2023-10-20)N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-quinone) is a degradation product of 6PPD, an antioxidant widely used in rubber tires. 6PPD-quinone enters aquatic ecosystems through ... -
Study of Elastin, Hydrolyzed Collagen and Collagen-like Products in a Tri-Layered Chitosan Membrane to Test Anti-Aging Skin Properties
(International Journal of Molecular Sciences 2023, 24(13), 11016, 2023-07-01)The use of animal testing in the cosmetic industry is already prohibited in more than 40 countries, including those of the EU. The pressure for it to be banned worldwide in the future is increasing, so ... -
A machine learning approach to predict cellular uptake of pBAE polyplexes
(Biomaterials Science 2023, 12(17), 5697-6002, 2023-09)The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ... -
High-consistency silicone rubber with reduced Young's modulus. An industrial option to dielectric silicone rubber
(Journal of Applied Polymer Science, 140(37), e54405, 2023-10-05)Flexible capacitive sensors based on silicone rubber have gained importance inboth academic and industrial fields due to their advantages, including lowpower consumption and high stability to temperature, ... -
Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish
(Chemosphere. 2024;355:141851, 2024-04-09)Fish have common neurotransmitter pathways with humans, exhibiting a significant degree of conservation and homology. Thus, exposure to fluoxetine makes fish potentially susceptible to biochemical and ... -
From propenolysis to enyne metathesis: tools for expedited assembly of 4a,8a-azaboranaphthalene and extended polycycles with embedded BN
(Chemical Science. 2024;15(15):5674-5680, 2024-03-07)The synthesis of BN-containing molecules, which have an interesting isosteric relationship to their parent all-C cores, has drawn a great deal of attention as an avenue to alter and tune molecular ... -
Karl Löwith i el natural transcendent: una proposta per fer front als perills de la fe en el progrés
(Compàs d'amalgama. 2024(9): 47-50, 2024-05-26)Segons el pensador alemany Karl Löwith, la fe en el progrés històric deriva de l’escatologia cristiana i la seva promesa de salvació. El progrés no ens diu res de cap a on ens encaminem com a humanitat ... -
Identification of critical process parameters for expansion of clinical grade human Wharton's jelly-derived mesenchymal stromal cells in stirred-tank bioreactors
(Biotechnology Journal. 2024;19:2300381, 2024-02-25)Cell therapies based on multipotent mesenchymal stromal cells (MSCs) are traditionally produced using 2D culture systems and platelet lysate- or serum-containing media (SCM). Although cost-effective for ... -
Formation of a Covalent Adduct in Retaining β-Kdo Glycosyl-Transferase WbbB via Substrate-Mediated Proton Relay
(ChemCatChem. 2024;16:e202400769, 2024-07-22)The GT99 domain of the membrane-anchored WbbB glycosyltransferase (WbbBGT99) catalyzes the transfer of 3-deoxy-D-manno-oct-2-acid (β-Kdo) to an O-antigen saccharide acceptor with retention of stereochemistry. ... -
Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
(Chemosphere. 2024;367:143612, 2024-11-05)A cost-effective Daphnia magna testing framework was applied to identify emerging hazards such as neurological and cardiovascular defects as well as antibiotic resistant genes (ARGs), related to ... -
Unconventional Optical Matter of Hybrid Metal–Dielectric Nanoparticles at Interfaces
(ACS Nano 2024;18(47):32746-32758, 2024-11-18)Optical matter, a transient arrangement formed by the interaction of light with micro/nanoscale objects, provides responsive and highly tunable materials that allow for controlling and manipulating light ... -
Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats
(2024-01-13)Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by ... -
Comparison Between Modal Analysis and Impedance-based Methods for Analysing Stability of Unbalanced Microgrids with Grid-forming Electronic Power Converters
(Journal of Modern Power Systems and Clean Energy 2023, 11(4), 1269 - 1281, 2023-07)Stability in unbalanced power systems has deserved little attention in the literature. Given the importance of this scenario in distribution systems with distributed generation, this paper revisits modal ... -
Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation
(Advanced Therapeutics 2023, 6 (11), 2300116, 2023-11)In this work, the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in water and to photo-inactivate bacterial strains ... -
Site-specific antibody masking enables conditional activation with different stimuli
(New Biotechnology 2023, 78, 2023-12)Antibody therapeutics show great potential to treat a variety of diseases. Often, the dose that can be safely administered is limited by side effects that arise from the interaction with the target ... -
Creation of Chemically Tri-Layered Collagen Crosslinked Membranes and Their Comparison with Ionically Tri-Layered Chitosan Crosslinked Membranes to Study Human Skin Properties
(International Journal of Molecular Sciences 2023, 24(17), 13443, 2023-09)In 2009, a new European regulation came into force that forbade the use of animals in the cosmetics industry. As a result, new alternatives were sought, taking into account the new ethical considerations. ...