Listando por materia "Fotosensibilització (Biologia)"
Mostrando ítems 1-13 de 13
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A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
(International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ... -
A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents
(Chemical Communications. Vol.51, n.26 (2015), p.5586-5589, 2014-12)Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The ... -
Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer
(Molecules. Vol.25, n.1 (2020), 213, 2020-01)We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ... -
Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy
(Chemical Communications. Vol.52, n.54 (2016), p.8405-8408, 2016-06)Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the photostability of miniSOG mutants and their ability to photooxidize ... -
Cluster and Kill: the Use of Clustering-Triggered Emission Materials for Singlet Oxygen Photosensitization in Antimicrobial Photodynamic Therapy
(Advanced Optical Materials 2025, 13 (3), 2402179, 2025-01-24)The emergence of light-based technologies is revolutionizing modern medicine and healthcare by enabling precise disease diagnosis and treatment through various luminescent agents and imaging techniques. ... -
Morphology effects on singlet oxygen production and bacterial photoinactivation efficiency by different silica-protoporphyrin IX nanocomposites
(RSC Advances. Vol.7, n.24 (2017), p.14422-14429, 2017-03)Different silica-protoporphyrin IX (PpIX) nanocomposites have been synthesized to evaluate the dependence of singlet oxygen production and bacterial inactivation efficiency on the morphology of the ... -
Octanol-water partition coefficients of highly hydrophobic photodynamic therapy drugs: a computational study
(Afinidad. Vol.70, n.564 (2013), p.250-256, 2013-10)Photodynamic therapy is a novel treatment for solid tumors based on the selective induction of cell death by the generation of cytotoxic reactive oxygen species within neoplastic tissues. Oxygen ... -
Photodynamic synergistic effect of pheophorbide a and doxorubicin in combined treatment against tumoral cells
(Cancers. Vol.9, n.2 (2017), 18, 2017-02)A combination of therapies to treat cancer malignancies is at the forefront of research with the aim to reduce drug doses (ultimately side effects) and diminish the possibility of resistance emergence ... -
Photosensitizing proteins for antibacterial photodynamic inactivation
(Translational Biophotonics. Vol.2, n.1-2 (2020) e201900031, 2020-05)We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ... -
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ... -
Riboflavin-binding proteins for singlet oxygen production
(Photochemical & Photobiological Sciences 2022, 21, 1545–1555, 2022)miniSOG, developed as the first fully genetically encoded singlet oxygen photosensitiser, has found various applications in cell imaging and functional studies. Yet, miniSOG has suboptimal properties, ... -
Subdiffraction localization of a nanostructured photosensitizer in bacterial cells
(Scientific Reports. Vol.5, 15564 (2015), 2015-10)Antibacterial treatments based on photosensitized production of reactive oxygen species is a promising approach to address local microbial infections. Given the small size of bacterial cells, identification ... -
Tuning the local solvent composition at a drug carrier surface: the effect of dimethyl sulfoxide/water mixture on the photofunctional properties of hypericin–β-lactoglobulin complexes
(Journal of Materials Chemistry B. Vol.5, n.8 (2017), p.1633-1641, 2017-01)Aggregation is a major problem for the anti-microbial photodynamic applications of hydrophobic photosensitizers since it strongly reduces the amount of singlet oxygen generated in aqueous solutions. ...