A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

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Author
Nonell, Santi
Planas, Oriol
Gallavardin, Thibault
Other authors
Universitat Ramon Llull. IQS
Publication date
2014-12
URI http://hdl.handle.net/20.500.14342/1082
DOI
https://doi.org/10.1039/C4CC09070E
Abstract
Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.
Document Type
Article
Published version
Language
English
Subject (CDU)
54 - Chemistry. Crystallography. Mineralogy
Keywords
Nanomedicina
Fotosensibilització (Biologia)
Fluorescència
Porphycenes
Photosensitization
Pages
4 p.
Publisher
Royal Society of Chemistry
Is part of
Chemical Communications. Vol.51, n.26 (2015), p.5586-5589
Grant agreement number
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2014FI_B 00777
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© The Royal Society of Chemistry

Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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