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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorHernáez, Álvaro
dc.contributor.authorSoria Florido, María Trinidad
dc.contributor.authorSchröder, Helmut, 1958-
dc.contributor.authorRos Rahola, Emilio
dc.contributor.authorPintó Sala, Xavier
dc.contributor.authorEstruch Riba, Ramon
dc.contributor.authorSalas Salvadó, Jordi
dc.contributor.authorCorella Piquer, Dolores
dc.contributor.authorArós, Fernando
dc.contributor.authorSerra Majem, Lluís
dc.contributor.authorMartínez-González, Miguel Ángel, 1957-
dc.contributor.authorFiol Sala, Miguel
dc.contributor.authorLapetra, José
dc.contributor.authorElosua Llanos, Roberto
dc.contributor.authorLamuela Raventós, Rosa Ma.
dc.contributor.authorFitó Colomer, Montserrat
dc.date.accessioned2019-10-22T14:27:07Z
dc.date.accessioned2023-07-12T12:05:31Z
dc.date.available2019-10-22T14:27:07Z
dc.date.available2023-07-12T12:05:31Z
dc.date.created2018-12
dc.date.issued2019-06
dc.identifier.urihttp://hdl.handle.net/20.500.14342/759
dc.description.abstractBackground High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.eng
dc.format.extent15 p.cat
dc.language.isoengcat
dc.publisherPublic Library of Science (PLoS)cat
dc.relation.ispartofPLoS One, 2019, vol. 14, núm. 6: e0218533cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherSistema cardiovascular -- Malalties -- Factors de risccat
dc.subject.otherLipoproteïnes de densitat altacat
dc.subject.otherLipoproteïnes de densitat baixacat
dc.subject.otherColesterolcat
dc.titleRole of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examinationcat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc616.1
dc.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0218533cat


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