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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorLucana, Maria C.
dc.contributor.authorLucchi, Roberta
dc.contributor.authorGosselet, Fabien
dc.contributor.authorDíaz Perlas, Cristina
dc.contributor.authorOller Salvia, Benjamí
dc.date.accessioned2025-03-26T19:12:27Z
dc.date.available2025-03-26T19:12:27Z
dc.date.issued2023-12-11
dc.identifier.issn2633-0679ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/5186
dc.description.abstractProtein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.ca
dc.format.extent5 p.ca
dc.language.isoengca
dc.publisherRoyal Society of Chemistryca
dc.relationSupplementary filesca
dc.relation.ispartofRSC Chemical Biology. 2024;5(1):7-11ca
dc.relation.urihttps://www.rsc.org/suppdata/d3/cb/d3cb00194f/d3cb00194f1.pdfca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherProtein therapeuticsca
dc.subject.otherbrainca
dc.titleBrainBike peptidomimetic enables efficient transport of proteins across brain endotheliumca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://doi.org/10.1039/D3CB00194Fca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIN-AEI/FPU/19/03216ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/MSCA-PF/101063066ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/la Caixa/JuniorLeaders/11840002ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/la Caixa/INPhINIT/100010434ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/MSCA /847648ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIN-AEI/PN I+D/PID2020-117486RA-I00ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/AECC/IDEAS/IDEAS211057OLLEca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SGR-2021-00537ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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