BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium
Author
Publication date
2023-12-11ISSN
2633-0679
Abstract
Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Protein therapeutics
brain
Pages
5 p.
Publisher
Royal Society of Chemistry
Is part of
RSC Chemical Biology. 2024;5(1):7-11
Grant agreement number
info:eu-repo/grantAgreement/MCIN-AEI/FPU/19/03216
info:eu-repo/grantAgreement/EC/MSCA-PF/101063066
info:eu-repo/grantAgreement/la Caixa/JuniorLeaders/11840002
info:eu-repo/grantAgreement/la Caixa/INPhINIT/100010434
info:eu-repo/grantAgreement/EC/MSCA /847648
info:eu-repo/grantAgreement/MCIN-AEI/PN I+D/PID2020-117486RA-I00
info:eu-repo/grantAgreement/AECC/IDEAS/IDEAS211057OLLE
info:eu-repo/grantAgreement/SUR del DEC/SGR/SGR-2021-00537
Related items
Supplementary files
Link to the related item
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
