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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorSoldevila-Domenech, Natalia
dc.contributor.authorFagundo, Ana Beatriz
dc.contributor.authorCuenca Royo, Aida
dc.contributor.authorForcano Gamazo, Laura
dc.contributor.authorGomis-Gonzalez, Maria
dc.contributor.authorBoronat, Anna
dc.contributor.authorPastor, Antoni
dc.contributor.authorCastañer, Olga
dc.contributor.authorZomeño, Dolors
dc.contributor.authorGoday, Alberto
dc.contributor.authorDierssen, Mara
dc.contributor.authorBaghizadeh Hosseini, Khashayar
dc.contributor.authorRos Rahola, Emilio
dc.contributor.authorCorella Piquer, Dolores
dc.contributor.authorMartínez-González, Miguel Ángel
dc.contributor.authorSalas Salvadó, Jordi
dc.contributor.authorFernández-Aranda, Fernando
dc.contributor.authorFitó Colomer, Montserrat
dc.contributor.authorde la Torre, Rafael
dc.date.accessioned2025-02-24T21:40:46Z
dc.date.available2025-02-24T21:40:46Z
dc.date.created2023-12
dc.date.issued2024-06
dc.identifier.urihttp://hdl.handle.net/20.500.14342/5019
dc.description.abstractBackground The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) and N-acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved in multiple neurological disorders and metabolic processes. Hypothesizing that eCBs and NAEs will be biomarkers of a MedDiet intervention and will be related to the cognitive response, we investigated this relationship according to sex and apolipoprotein E (APOE) genotype, which may affect eCBs and cognitive performance. Methods This was a prospective cohort study of 102 participants (53.9% women, 18.8% APOE-ɛ4 carriers, aged 65.6 ± 4.5 years) from the PREDIMED-Plus-Cognition substudy, who were recruited at the Hospital del Mar Research Institute (Barcelona). All of them presented metabolic syndrome plus overweight/obesity (inclusion criteria of the PREDIMED-Plus) and normal cognitive performance at baseline (inclusion criteria of this substudy). A comprehensive battery of neuropsychological tests was administered at baseline and after 1 and 3 years. Plasma concentrations of eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and N-docosahexaenoylethanolamine (DHEA), were also monitored. Baseline cognition, cognitive changes, and the association between eCBs/NAEs and cognition were evaluated according to gender (crude models), sex (adjusted models), and APOE genotype. Results At baseline, men had better executive function and global cognition than women (the effect size of gender differences was − 0.49, p = 0.015; and − 0.42, p = 0.036); however, these differences became nonsignificant in models of sex differences. After 3 years of MedDiet intervention, participants exhibited modest improvements in memory and global cognition. However, greater memory changes were observed in men than in women (Cohen’s d of 0.40 vs. 0.25; p = 0.017). In men and APOE-ε4 carriers, 2-AG concentrations were inversely associated with baseline cognition and cognitive changes, while in women, cognitive changes were positively linked to changes in DHEA and the DHEA/AEA ratio. In men, changes in the OEA/AEA and OEA/PEA ratios were positively associated with cognitive changes. Conclusions The MedDiet improved participants’ cognitive performance but the effect size was small and negatively influenced by female sex. Changes in 2-AG, DHEA, the OEA/AEA, the OEA/PEA and the DHEA/AEA ratios were associated with cognitive changes in a sex- and APOE-dependent fashion. These results support the modulation of the endocannabinoid system as a potential therapeutic approach to prevent cognitive decline in at-risk populations.ca
dc.format.extent20 p.ca
dc.language.isoengca
dc.publisherBioMed Centralca
dc.relation.ispartofNutritional journal, 2024, 23: 61ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherDieta mediterràniaca
dc.subject.otherCompostos endocannabinoidesca
dc.subject.otherDiferències entre sexesca
dc.subject.otherCognicióca
dc.subject.otherSíndrome metabòlicaca
dc.subject.other2-AGca
dc.titleRelationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet interventionca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.identifier.doihttps://doi.org/10.1186/s12937-024-00966-wca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SLT006/17/00246ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SLT002/16/00045ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SLT006/17/00077ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI13/00233ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI13/00728ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI13/01123ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI13/00462ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI16/00533ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI16/00366ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI16/01094ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI16/00501ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI17/01167ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI19/00017ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI19/00781ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI19/01032ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ERDF/PI19/00576ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Eat2beNICE/ H2020-SFS-2016-2ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Eat2beNICE/H2020-SC1-BHC-2018-2020ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 138ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/Predoctoral grant/FI_B2021/00104ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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