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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorGonzalez-Franquesa, Alba
dc.contributor.authorGama Pérez, Pau
dc.contributor.authorKulis, Marta
dc.contributor.authorSzczepanowska, Karolina
dc.contributor.authorDahdah, Norma
dc.contributor.authorMoreno-Gomez, Sonia
dc.contributor.authorLatorre-Pellicer, Ana
dc.contributor.authorFernández-Ruiz, Rebeca
dc.contributor.authorAguilar-Mogas, Antoni
dc.contributor.authorHoffman, Anne
dc.contributor.authorMonelli, Erika
dc.contributor.authorSamino, Sara
dc.contributor.authorMiró-Blanch, Joan
dc.contributor.authorOemer, Gregor
dc.contributor.authorDuran, Xavier
dc.contributor.authorSanchez-Rebordelo, Estrella
dc.contributor.authorSchneeberger, Marc
dc.contributor.authorObach, Merce
dc.contributor.authorMontane Mogas, Joel
dc.contributor.authorCastellano, Giancarlo
dc.contributor.authorChapaprieta, Vicente
dc.contributor.authorSun, Wenfei
dc.contributor.authorNavarro, Lourdes
dc.contributor.authorPrieto, Ignacio
dc.contributor.authorCastaño, Carlos
dc.contributor.authorNovials, Anna
dc.contributor.authorGomis, Ramon
dc.contributor.authorMonsalve, Maria
dc.contributor.authorClaret, Marc
dc.contributor.authorGraupera, Mariona
dc.contributor.authorSoria, Guadalupe
dc.contributor.authorWolfrum, Christian
dc.contributor.authorVendrell, Joan
dc.contributor.authorFernández-Veledo, Sonia
dc.contributor.authorEnríquez, José Antonio
dc.contributor.authorCarracedo, Angel
dc.contributor.authorPerales , José Carlos
dc.contributor.authorNogueiras, Ruben
dc.contributor.authorHerrero, Laura
dc.contributor.authorTrifunovic, Aleksandra
dc.contributor.authorKeller, Markus A.
dc.contributor.authorYanes, Oscar
dc.contributor.authorSales-Pardo, Marta
dc.contributor.authorGuimerà, Roger
dc.contributor.authorBlüher, Matthias
dc.contributor.authorMartín-Subero, José Ignacio
dc.contributor.authorGarcia-Roves, Pablo M.
dc.date.accessioned2024-03-05T20:48:35Z
dc.date.available2024-03-05T20:48:35Z
dc.date.created2022-03
dc.date.issued2022-06
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3984
dc.description.abstractMetabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.ca
dc.format.extent18 p.ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofRedox Biology, 2022, 54: 102353ca
dc.rights© L'autor/aca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherObesitatca
dc.subject.otherPlasticitat metabòlicaca
dc.subject.otherTeixit adipós visceralca
dc.subject.otherMitocondris -- Malaltiesca
dc.subject.otherExercicica
dc.subject.otherRestricció calòricaca
dc.subject.otherEnfocament multiorgànicca
dc.subject.otherObesitat -- Cirurgiaca
dc.subject.otherEmpremta metabòlicaca
dc.titleRemission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissueca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc577ca
dc.subject.udc613ca
dc.identifier.doihttps://doi.org/10.1016/j.redox.2022.102353ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/PN I+D+i/BFU2011-24679ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i FEDER/PI15/00701ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-SGR-204ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-SGR-736ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-SGR-896ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D+i/RTI2018- 093864-B-I00ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D+i/BFU2017-87958ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/ERC/H2020/725004ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D+i/SAF2013-45887-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D+i/SAF2017-83813-C3-1-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FEDER i CIBEROBN/CB06/03/0001ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017SGR278ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundació la Marató de TV3/201627–30ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/RYC/RYC-2009-05158ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/NNF/NNF18CC0034900ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/UB/Predoctoral fellowship/APIF-UBca
dc.relation.projectIDinfo:eu-repo/grantAgreement/GRF/Posdoctoral Grant/SFB 1218ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/MCSA/675610ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/FPI/BES-2013-062796ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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