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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorLampousi, Anna-Maria
dc.contributor.authorCarlsson, Sofia
dc.contributor.authorEdwall Löfvenborg, Josefin
dc.contributor.authorCabrera-Castro, Natalia
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorFranks, Paul W.
dc.contributor.authorHampe, Christiane
dc.contributor.authorJakszyn, Paula
dc.contributor.authorKoulman, Albert
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorMoreno Iribas, Conchi
dc.contributor.authorNilsson, Peter M.
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPapier, Keren
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorSharp, Stephen J.
dc.contributor.authorRolandsson, Olov
dc.contributor.authorWareham, Nicholas
dc.date.accessioned2024-02-28T20:31:50Z
dc.date.available2024-02-28T20:31:50Z
dc.date.created2023-03
dc.date.issued2023-06
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3966
dc.description.abstractAims/hypothesis Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against GAD65 (GAD65Ab) on the incidence of adult-onset diabetes. Methods We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onset diabetes cases and a subcohort of 14,866 randomly selected individuals. Adjusted Prentice-weighted Cox regression estimated HRs and 95% CIs of diabetes in relation to 1 SD lower plasma phospholipid 15:0 and/or 17:0 concentrations or their main contributor, dairy intake, among GAD65Ab-negative and -positive individuals. Interactions between tertiles of OCFA and GAD65Ab status were estimated by proportion attributable to interaction (AP). Results Low concentrations of OCFA, particularly 17:0, were associated with a higher incidence of adult-onset diabetes in both GAD65Ab-negative (HR 1.55 [95% CI 1.48, 1.64]) and GAD65Ab-positive (HR 1.69 [95% CI 1.34, 2.13]) individuals. The combination of low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity conferred an HR of 7.51 (95% CI 4.83, 11.69), with evidence of additive interaction (AP 0.25 [95% CI 0.05, 0.45]). Low dairy intake was not associated with diabetes incidence in either GAD65Ab-negative (HR 0.98 [95% CI 0.94, 1.02]) or GAD65Ab-positive individuals (HR 0.97 [95% CI 0.79, 1.18]). Conclusions/interpretation Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab positivity to adult-onset diabetes.ca
dc.format.extent12 p.ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofDiabetologia, 2023, 66: 1460-1471ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherDiabetisca
dc.subject.otherGAD65Abca
dc.subject.otherÀcid heptadecanoicca
dc.subject.otherAutoimmunitatca
dc.subject.otherOCFAca
dc.subject.otherÀcid pentadecanoicca
dc.titleInteraction between plasma phospholipid odd‑chain fatty acids and GAD65 autoantibodies on the incidence of adult‑onset diabetes: the EPIC‑InterAct case–cohort studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc579ca
dc.subject.udc616.3ca
dc.identifier.doihttps://doi.org/10.1007/s00125-023-05948-xca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/LSHM_CT_2006_037197ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/NIH/DK-26190 (CSH)ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/NIH/DK-26190 (CSH)ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/Västerbotten County Council, UU i MRC/ MC_UU_12015/1 (NJW)ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SRCH/FORTE 2018-00337ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/NNF/NNF19OC0057274ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SRC/2018- 03035ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SDF/DIA2022-735ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII i ESF/CPII20/00009ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MIER i GCDR/82DZD03D03ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MRC Epidemiology Unit/MC_UU_00006/1ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MRC Epidemiology Unit/MC_UU_00006/3ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/NIH i CBRC/NIHR203312ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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