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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorHernáez, Álvaro
dc.contributor.authorSkåra, Karoline Hansen
dc.contributor.authorPage, Christian Magnus
dc.contributor.authorMitter, Vera R.
dc.contributor.authorHernández Hernández, Marta
dc.contributor.authorMagnus, Per
dc.contributor.authorNjølstad, Pål R.
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorCorfeld, Elizabeth C.
dc.contributor.authorHavdahl, Alexandra
dc.contributor.authorNæss, Øyvind
dc.contributor.authorBrumpton, Ben
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorLawlor, Deborah A.
dc.contributor.authorFraser, Abigail
dc.contributor.authorMagnus, Maria Christine
dc.date.accessioned2024-02-25T15:55:42Z
dc.date.available2024-02-25T15:55:42Z
dc.date.created2023-08
dc.date.issued2024-01
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3956
dc.description.abstractBackground Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman’s underlying risk for coronary heart disease (CHD). We estimated associations of maternal and paternal genetically predicted liability for CHD with lifelong risk of APOs. We hypothesized that associations would be found for women, but not their male partners (negative controls). Methods We studied up to 83,969‬ women (and up to 55,568‬ male partners) from the Norwegian Mother, Father and Child Cohort Study or the Trøndelag Health Study with genotyping data and lifetime history of any APO in their pregnancies (1967–2019) in the Medical Birth Registry of Norway (miscarriage, stillbirth, hypertensive disorders of pregnancy, gestational diabetes, small for gestational age, large for gestational age, and spontaneous preterm birth). Maternal and paternal genetic risk scores (GRS) for CHD were generated using 148 gene variants (p-value < 5 × 10−8, not in linkage disequilibrium). Associations between GRS for CHD and each APO were determined using logistic regression, adjusting for genomic principal components, in each cohort separately, and combined using fixed effects meta-analysis. Results One standard deviation higher GRS for CHD in women was related to increased risk of any hypertensive disorders of pregnancy (odds ratio [OR] 1.08, 95% confidence interval [CI] 1.05–1.10), pre-eclampsia (OR 1.08, 95% CI 1.05–1.11), and small for gestational age (OR 1.04, 95% CI 1.01–1.06). Imprecise associations with lower odds of large for gestational age (OR 0.98, 95% CI 0.96–1.00) and higher odds of stillbirth (OR 1.04, 95% CI 0.98–1.11) were suggested. These findings remained consistent after adjusting for number of total pregnancies and the male partners’ GRS and restricting analyses to stable couples. Associations for other APOs were close to the null. There was weak evidence of an association of paternal genetically predicted liability for CHD with spontaneous preterm birth in female partners (OR 1.02, 95% CI 0.99–1.05), but not with other APOs. Conclusions Hypertensive disorders of pregnancy, small for gestational age, and stillbirth may unmask women with a genetically predicted propensity for CHD. The association of paternal genetically predicted CHD risk with spontaneous preterm birth in female partners needs further exploration.ca
dc.format.extent11 p.ca
dc.language.isoengca
dc.publisherBioMed Centralca
dc.relation.ispartofBMC Medicine, 2024, 22:35ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherMalalties coronàries -- Aspectes genèticsca
dc.subject.otherEmbaràs -- Complicacionsca
dc.subject.otherGenèticaca
dc.subject.otherResponsabilitat genètica dels paresca
dc.subject.otherMoBaca
dc.subject.otherHUNTca
dc.titleParental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc616.1ca
dc.subject.udc618ca
dc.identifier.doihttps://doi.org/10.1186/s12916-023-03223-9ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant agreement 947684ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant agreement 964874ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant agreement 101021566ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/262700ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/320656ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/223273ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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