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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorCayssials, Valerie
dc.contributor.authorBuckland, Genevieve
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorBonet, Catalina
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkie, Guri
dc.contributor.authorAune, Dagfnn
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorBueno de Mesquita, H. Bas
dc.contributor.authorDerksen, Jeroen
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorFerrari, Pietro
dc.contributor.authorFranklin, Oscar
dc.contributor.authorBodén, Stina
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorAmiano, Pilar
dc.contributor.authorTumino, Rosario
dc.contributor.authorMolina-Montes, Esther
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorRebours, Vinciane
dc.contributor.authorKatzke, Verena Andrea
dc.contributor.authorAgudo, Antonio
dc.contributor.authorJakszyn, Paula
dc.date.accessioned2024-02-08T16:45:42Z
dc.date.created2021-10
dc.date.issued2022-01
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3910
dc.description.abstractPurpose There is existing evidence on the potential role of chronic infammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-infammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary infammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The infammatory potential of the diet was estimated using an Infammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confdence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically signifcant interactions. Conclusion To the best of our knowledge, this is the frst prospective study reporting a positive relationship between the infammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.ca
dc.format.extent8 p.ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofEuropean Journal of Nutrition, 2022, 61: 2313-2320ca
dc.rights© Springer-Verlag GmbH Germany. Tots els drets reservatsca
dc.subject.otherPàncrees -- Càncerca
dc.subject.otherEpidemiologiaca
dc.subject.otherInvestigació prospectivaca
dc.subject.otherDietèticaca
dc.subject.otherDieta proinflamatoriaca
dc.titleInflammatory potential of diet and pancreatic cancer risk in the EPIC studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/embargoedAccess
dc.date.embargoEnd2024-12-31T01:00:00Z
dc.embargo.terms36 mesosca
dc.subject.udc613ca
dc.subject.udc616ca
dc.identifier.doihttps://doi.org/10.1007/s00394-022-02809-yca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PI15/00639ca
dc.local.notesFitxer i embargament provisional. Cal revisar i actualitzar-hoca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca


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