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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorIglesias Vázquez, Lucía
dc.contributor.authorArija, Victoria
dc.contributor.authorAranda, Núria
dc.contributor.authorAglago, Elom K
dc.contributor.authorCross, Amanda J.
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorQuintana Pacheco, Daniel
dc.contributor.authorKühn, Tilman
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorTumino, Rosario
dc.contributor.authorRedondo‑Sánchez, Daniel
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorPalli, Domenico
dc.contributor.authorArdanaz, Eva
dc.contributor.authorLaouali, Nasser
dc.contributor.authorSonestedt, Emily
dc.contributor.authorDrake, Isabel
dc.contributor.authorRizzolo-Brime, Lucía
dc.contributor.authorSantiuste, Carmen
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorAmiano, Pilar
dc.contributor.authorAgudo, Antonio
dc.contributor.authorJakszyn, Paula
dc.date.accessioned2024-02-07T20:22:07Z
dc.date.available2024-02-07T20:22:07Z
dc.date.created2020-12
dc.date.issued2021-07
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3897
dc.description.abstractPurpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case–control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic infammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was signifcantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex diferences even after excluding participants with hsCRP>5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.ca
dc.format.extent14 p.ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofEuropean Journal of Nutrition, 2022, 61: 101-114ca
dc.rights© Springer Nature. Tots els drets reservatsca
dc.subject.otherFerritinaca
dc.subject.otherFerro en l'organismeca
dc.subject.otherExcès de ferroca
dc.subject.otherEPICca
dc.titleFactors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.terms12 mesosca
dc.subject.udc613ca
dc.identifier.doihttps://doi.org/10.1007/s00394-021-02625-wca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PI11/1486ca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca


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