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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorAgudo, Antonio
dc.contributor.authorCayssials, Valerie
dc.contributor.authorBonet, Catalina
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorAffret, Aurélie
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorKatzke, Verena Andrea
dc.contributor.authorSchübel, Ruth
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorPalli, Domenico
dc.contributor.authorGrioni, Sara
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno de Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorLasheras-Mayo, Maria Cristina
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorAmiano, Pilar
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorDias, Joana A.
dc.contributor.authorNilsson, Lena M.
dc.contributor.authorMyte, Robin
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorGunter, Marc
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorCross, Amanda J.
dc.contributor.authorTsilidis, Kostas
dc.contributor.authorRiboli, Elio
dc.contributor.authorJakszyn, Paula
dc.date.accessioned2024-02-07T20:14:15Z
dc.date.available2024-02-07T20:14:15Z
dc.date.issued2018-04
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3892
dc.description.abstractBackground Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. Results The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Conclusions Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach.ca
dc.format.extent10 p.ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofAmerican Journal of Clinical Nutrition, 2018, 107(4):607-616ca
dc.rights© American Society for Nutritionca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherEstómac -- Càncerca
dc.subject.otherNutricióca
dc.subject.otherDietèticaca
dc.subject.otherInvestigació prospectivaca
dc.subject.otherInflamació crònicaca
dc.titleInflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.terms12 mesosca
dc.subject.udc613ca
dc.subject.udc616ca
dc.identifier.doihttps://doi.org/10.1093/ajcn/nqy002ca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca


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© American Society for Nutrition
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/
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