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dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorWedekind, Roland
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorViallon, Vivian
dc.contributor.authorKeski-Rahkonen, Pekka
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorChajes, Veronique
dc.contributor.authorKatzke, Vna
dc.contributor.authorJohnson, Theron
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorAmiano, Pilar
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorRedondo-Sanchez, Daniel
dc.contributor.authorHuerta, José María
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPokharel, Pratik
dc.contributor.authorJakszyn, Paula
dc.contributor.authorTumino, Rosario
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSandanger, Torkjel M.
dc.contributor.authorWinkvist, Anna
dc.contributor.authorHultdin, Johan
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, Marc J.
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2024-02-02T12:36:47Z
dc.date.available2024-02-02T12:36:47Z
dc.date.created2021-11
dc.date.issued2022-08
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3847
dc.description.abstractBackground & aims Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Methods Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed. Results Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r = 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r = 0.5). Intake of most other foods and of carnitine showed little association with AC levels. Conclusions Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.ca
dc.format.extent11 p.ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofClinical nutrition, 2022, 41(8): 1735-1745ca
dc.rights© Elsevierca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherAcilcarnitinesca
dc.subject.otherMetabolòmicaca
dc.subject.otherAlimentacióca
dc.subject.otherDietaca
dc.subject.otherAminoàcids en la nutricióca
dc.subject.otherÀcids grassosca
dc.titleDeterminants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutritionca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc577ca
dc.subject.udc613ca
dc.identifier.doihttps://doi.org/10.1016/j.clnu.2022.05.020ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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