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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorGuerle Cavero, Rocío
dc.contributor.authorLleal Fontàs, Blanca
dc.contributor.authorBalfagón Costa, Albert
dc.date.accessioned2024-01-30T20:00:42Z
dc.date.available2024-01-30T20:00:42Z
dc.date.issued2021-06-23
dc.identifier.issn1996-1944ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3810
dc.description.abstractIn 2023, new legislation will ban the use of animals in the cosmetic industry worldwide. This fact, together with ethical considerations concerning the use of animals or humans in scientific research, highlights the need to propose new alternatives for replacing their use. The aim of this study is to create a tri-layered chitosan membrane ionically crosslinked with sodium tripolyphosphate (TPP) in order to simulate the number of layers in human skin. The current article highlights the creation of a membrane where pores were induced by a novel method. Swelling index, pore creation, and mechanical property measurements revealed that the swelling index of chitosan membranes decreased and, their pore formation and elasticity increased with an increase in the Deacetylation Grade (DDA). Additionally, the results demonstrate that chitosan’s origin can influence the elastic modulus value and reproducibility, with higher values being obtained with seashell than snow crab or shrimp shells. Furthermore, the data show that the addition of each layer, until reaching three layers, increases the elastic modulus. Moreover, if layers are crosslinked, the elastic modulus increases to a much greater extent. The characterization of three kinds of chitosan membranes was performed to find the most suitable material for studying different human skin properties.ca
dc.format.extent12 p.ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofMaterialsca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherChitosanca
dc.subject.otherCrosslinkingca
dc.subject.otherMembraneca
dc.subject.otherPoresca
dc.subject.otherLayersca
dc.subject.otherElasticityca
dc.subject.otherPermeationca
dc.subject.otherHuman skinca
dc.subject.otherEthicsca
dc.subject.otherQuitosanca
dc.subject.otherMembranes (Biologia)ca
dc.subject.otherElasticitatca
dc.subject.otherPermeabilitatca
dc.subject.otherPellca
dc.subject.otherÈticaca
dc.titleCreation of Ionically Crosslinked Tri-Layered Chitosan Membranes to Simulate Different Human Skin Propertiesca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc547ca
dc.identifier.doihttps://doi.org/10.3390/ma14071807ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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