Creation of Ionically Crosslinked Tri-Layered Chitosan Membranes to Simulate Different Human Skin Properties
Author
Guerle Cavero, Rocío
Lleal Fontàs, Blanca
Balfagón Costa, Albert
Other authors
Universitat Ramon Llull. IQS
Publication date
2021-06-23ISSN
1996-1944
Abstract
In 2023, new legislation will ban the use of animals in the cosmetic industry worldwide. This fact, together with ethical considerations concerning the use of animals or humans in scientific research, highlights the need to propose new alternatives for replacing their use. The aim of this study is to create a tri-layered chitosan membrane ionically crosslinked with sodium tripolyphosphate (TPP) in order to simulate the number of layers in human skin. The current article highlights the creation of a membrane where pores were induced by a novel method. Swelling index, pore creation, and mechanical property measurements revealed that the swelling index of chitosan membranes decreased and, their pore formation and elasticity increased with an increase in the Deacetylation Grade (DDA). Additionally, the results demonstrate that chitosan’s origin can influence the elastic modulus value and reproducibility, with higher values being obtained with seashell than snow crab or shrimp shells. Furthermore, the data show that the addition of each layer, until reaching three layers, increases the elastic modulus. Moreover, if layers are crosslinked, the elastic modulus increases to a much greater extent. The characterization of three kinds of chitosan membranes was performed to find the most suitable material for studying different human skin properties.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
547 - Organic chemistry
Keywords
Chitosan
Crosslinking
Membrane
Pores
Layers
Elasticity
Permeation
Human skin
Ethics
Quitosan
Membranes (Biologia)
Elasticitat
Permeabilitat
Pell
Ètica
Pages
12 p.
Publisher
MDPI
Is part of
Materials
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/