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dc.contributorUniversitat Ramon Llull. Facultat de Psicologia, Ciències de l'Educació i de l'Esport Blanquerna
dc.contributorUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.contributor.authorMagaña, Juan Carlos
dc.contributor.authorDeus, Cláudia Maria
dc.contributor.authorBaldellou, Laura
dc.contributor.authorAvellanet, Merce
dc.contributor.authorGea-Rodríguez, Elvira
dc.contributor.authorEnriquez-Calzada, Silvia
dc.contributor.authorLaguna, Ariadna
dc.contributor.authorMartínez-Vicente, Marta
dc.contributor.authorHernández-Vara, Jorge
dc.contributor.authorGiné-Garriga, Maria
dc.contributor.authorPereira, Susana Patricia
dc.contributor.authorMontane Mogas, Joel
dc.date.accessioned2023-12-10T22:34:46Z
dc.date.available2023-12-10T22:34:46Z
dc.date.issued2023-11-23
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3644
dc.description.abstractParkinson’s disease (PD) is characterized by the progressive dopaminergic neuron degeneration, resulting in striatal dopamine deficiency. Mitochondrial dysfunction and oxidative stress are associated with PD pathogenesis. Physical activity (PA) has been shown to ameliorate neurological impairments and to impede age-related neuronal loss. In addition, skin fibroblasts have been identified as surrogate indicators of pathogenic processes correlating with clinical measures. The PARKEX study aims to compare the effects of two different PA programs, analyzing the impact on mitochondrial function in patients’ skin fibroblasts as biomarkers for disease status and metabolic improvement. Early-stage PD patients (n = 24, H&Y stage I to III) will be randomized into three age- and sex-matched groups. Group 1 (n = 8) will undergo basic physical training (BPT) emphasizing strength and resistance. Group 2 (n = 8) will undergo BPT combined with functional exercises (BPTFE), targeting the sensorimotor pathways that are most affected in PD (proprioception-balance-coordination) together with cognitive and motor training (Dual task training). Group 3 (n = 8) will serve as control (sedentary group; Sed). Participants will perform three sessions per week for 12 weeks. Assessment of motor function, quality of life, sleep quality, cognitive aspects and humor will be conducted pre- and post-intervention. Patient skin fibroblasts will be collected before and after the intervention and characterized in terms of metabolic remodeling and mitochondrial bioenergetics. Ethical approval has been given to commence this study. This trial is registered at clinicaltrials.gov (NCT05963425).ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherPublic Library of Science (PLoS)ca
dc.relation.ispartofPLoS ONE 18(11): e0293774ca
dc.rightsAttribution 4.0 International*
dc.rights© L'autor/aca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherParkinson, Malaltia deca
dc.subject.otherActivitat físicaca
dc.titleInvestigating the impact of physical activity on mitochondrial function in Parkinson’s disease (PARKEX): Study protocol for A randomized controlled clinical trialca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0293774ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/URL i SUR del REU/Projectes de recerca PDI/2021-URL-Proj-004ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FPCEEB/APR-FPCEE2122/04ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FEDER/CENTRO2020/CENTRO-01-0246-FEDER-000010ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCT/2022.01232.PTDCca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCT/UIDB/04539/2020ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCT/UIDP/04539/2020ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCT/LA/P/0058/2020ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCT/PosDoctoral fellowship/SFRH/BPD/116061/2016ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/URL i SUR del REU/Projectes de recerca PDI/2023-URL-Proj-016ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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