Articles publicats en revistes: Envíos recientes
Mostrando ítems 341-360 de 733
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1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications
(Pharmaceuticals 2021;14(10):1029, 2021-10-09)Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members ... -
Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus
(Molecular Therapy Oncology 2021;21:47-61, 2021-03-18)Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. ... -
Design and Evaluation of a User Experience Questionnaire for Remote Labs
(IEEE Access, 2021-03-29)Remote laboratories have been in use for 25 years now. Whereas several learning oriented meta-analyses exist, validated and agreed-upon tools for assessing the user experience are not readily available. ... -
Production Scheduling of Personalized Fashion Goods in a Mass Customization Environment
(Sustainability 2022, 14(1), 538, 2022-01)The COVID-19 pandemic has put fashion manufacturers’ needs for optimization in the spotlight. This study argues that mass customization is becoming increasingly instrumental for offering consumers ... -
Malin restoration as proof of concept for gene therapy for Lafora disease
(Brain Communications 2022, 4(4), fcac168, 2022)Lafora disease is a fatal neurodegenerative childhood dementia caused by loss-of-function mutations in either the laforin or malin gene. The hallmark of the disease is the accumulation of abnormal ... -
Measuring the provincial supply of higher education institutions in China
(China Economic Review 2022, 71, 101724, 2022-02)This paper proposes and estimates three novel higher education indices for 31 Chinese provinces: i) the Chinese Higher Education Density Index (CHEDI) to analyze the evolution of the quantitative ... -
Measuring the sustainable development goals: A poset analysis
(Ecological Indicators 2022, 145, 109605, 2022-12)Sustainability requires balanced development. The economy, society and the environment all need to be pursued simultaneously. In this context, the issue of incomparabilities among different dimensions ... -
Recent advances in the pharmacological targeting of ubiquitin-regulating enzymes in cancer
(Seminars in Cell & Developmental Biology 2022, 132, 213-229, 2022-12)As a post-translational modification that has pivotal roles in protein degradation, ubiquitination ensures that intracellular proteins act in a precise spatial and temporal manner to regulate diversified ... -
Analysis of laccase‐like enzymes secreted by fungi isolatedfrom a cave in northern Spain
(Microbiology Open 2022, 11(2), e1279, 2022-04)Laccases belong to a family of multicopper enzymes able to oxidize a broad spectrum of organic compounds. Despite the well-known property of laccases to carry out bleaching and degradation of industrial ... -
Mechanical performance of additively manufactured lightweight cellular solids: Influence of cell pattern and relative density on the printing time and compression behavior
(Materials & Design Volume 2022, 215, 110474, 2022-03)A comprehensive investigation is presented on the Fused Filament Fabrication (FFF) technology’s possibilities to create cellular solids with a broad spectrum of specific stiffness and strength, modifying ... -
Model food soils for investigating cleaning: A review
(Food and Bioproducts Processing 2022, 136, 249-296, 2022-11)Cleaning operations are performed regularly throughout the food industry. This review focuses on the removal of strongly adherent fouling deposits which compromise the performance and hygienic status ... -
Mutated RAS-associating proteins and ERK activation in relapse/refractory diffuse large B cell lymphoma
(Scientific Reports 2022, 12, 779, 2022)Diffuse large B cell lymphoma (DLBCL) is successfully treated with combination immuno-chemotherapy, but relapse with resistant disease occurs in ~ 40% of patients. However, little is known regarding ... -
Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives
(International Journal of Molecular Sciences 2022, 23(4), 2226, 2022-02)Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known ... -
Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
(Journal of Medicinal Chemistry, 2022, 65(8), 6070-6087, 2022-04-28)Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding ... -
Photosensitive EGFR-Targeted Nanocarriers for Combined Photodynamic and Local Chemotherapy
(Pharmaceutics 2022, 14(2), 405, 2022-02)The major limitation of any cancer therapy lies in the difficulty of precisely controlling the localization of the drug in the tumor cells. To improve this drawback, our study explores the use of ... -
Plasma-induced nanostructured metallic silver surfaces: study of bacteriophobic effect to avoid bacterial adhesion on medical devices
(Heliyon, 2022, 8(10), e10842, 2022-10)Biofilm formation in medical devices represents one of the major problems for the healthcare system, especially those that occur on implantable silicone-based devices. To provide a general solution to ... -
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
(Progress in Neuro-Psychopharmacology and Biological Psychiatry 2022, 117, 110562, 2022-07)N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties ... -
Riboflavin-binding proteins for singlet oxygen production
(Photochemical & Photobiological Sciences 2022, 21, 1545–1555, 2022)miniSOG, developed as the first fully genetically encoded singlet oxygen photosensitiser, has found various applications in cell imaging and functional studies. Yet, miniSOG has suboptimal properties, ... -
Selective dissolution of polysulfone support material of fused filament fabricated Ultem 9085 parts
(Polymer Testing 2022, 108, 107495, 2022-04)One of the main advantages of 3D printing lies in the fact that the desired object is constructed layer by layer, enabling the production of complex geometries otherwise unfeasible with conventional ... -
SPEEK and SPPO Blended Membranes for Proton Exchange Membrane Fuel Cells
(Membranes 2022, 12(3), 263, 2022-03)In fuel cell applications, the proton exchange membrane (PEM) is the major component where the balance among dimensional stability, proton conductivity, and durability is a long-term trail. In this ...