Listando Articles publicats en revistes por materia "577"
Mostrando ítems 1-19 de 19
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A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
(International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ... -
Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer
(Molecules. Vol.25, n.1 (2020), 213, 2020-01)We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ... -
Charting the metabolic landscape of the facultative methylotroph bacillus methanolicus
(Msystems. Vol.5, n.5 (2020), e00745-20, 2020-09)Bacillus methanolicus MGA3 is a thermotolerant and relatively fast-growing methylotroph able to secrete large quantities of glutamate and lysine. These natural characteristics make B. methanolicus a ... -
Culture and differentiation of human hair follicle dermal papilla cells in a soft 3D self-assembling peptide scaffold
(Biomolecules. Vol.10, n.5 (2020), 684, 2020-05)Hair follicle dermal papilla cells (HFDPC) are a specialized cell population located in the bulge of the hair follicle with unique characteristics such as aggregative behavior and the ability to induce ... -
Different mechanisms that promote protein monoubiquitination
(Afinidad. Vol.72, n.570 (2015), p.95-100, 2015-04)Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity ... -
Do folate-receptor targeted liposomal photosensitizers enhance photodynamic therapy selectivity?
(Biochimica et Biophysica Acta (BBA) -Biomembranes. Vol.1808, n.4 (2011), p.1063-1071, 2011-01)One of the current goals in photodynamic therapy research is to enhance the selective targeting of tumor cells in order to minimize the risk and the extension of unwanted side-effects caused by normal ... -
Glycosidases and glycosynthases in enzymatic synthesis of oligosaccharides: an overview
(Afinidad. Vol.59, n.500 (2002), p.295-313, 2002)Retaining glycosidases have been extensively studied for the synthesis of oligosaccharides and glycoconjugates as a convenient enzymatic approach to achieve the required regio- and stereoselectivity in ... -
Nanoscale characterization coupled to multi-parametric optimization of Hi5 cell transient gene expression
(Applied Microbiology and Biotechnology, 2018-10-13)Polyethylenimine (PEI)-based transient gene expression (TGE) is nowadays a well-established methodology for rapid protein production in mammalian cells, but it has been used to a much lower extent in ... -
Octanol-water partition coefficients of highly hydrophobic photodynamic therapy drugs: a computational study
(Afinidad. Vol.70, n.564 (2013), p.250-256, 2013-10)Photodynamic therapy is a novel treatment for solid tumors based on the selective induction of cell death by the generation of cytotoxic reactive oxygen species within neoplastic tissues. Oxygen ... -
On the mechanism of Candida tropicalis biofilm reduction by the combined action of naturally-occurring anthraquinones and blue light
(PLoS ONE. Vol.12, n.7 (2017), e0181517, 2017-07)The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of ... -
Photosensitizing proteins for antibacterial photodynamic inactivation
(Translational Biophotonics. Vol.2, n.1-2 (2020) e201900031, 2020-05)We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ... -
Preparative scale production of recombinant human transthyretin for biophysical studies of protein-ligand and protein-protein interactions
(International Journal of Molecular Sciences. Vol.21, n.24 (2020), 9640, 2020-12)Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial ... -
Singlet oxygen in antimicrobial photodynamic therapy: photosensitizer-dependent production and decay in E. coli
(Molecules. Vol.18, n.3 (2013), p.2712-2725, 2013-02)Several families of photosensitizers are currently being scrutinized for antimicrobial photodynamic therapy applications. Differences in physical and photochemical properties can lead to different ... -
Smooth muscle cells orchestrate the endothelial cell response to flow and injury
(Circulation. Vol.121, n.20 (2010), p.2192–2199, 2010-05)Background—Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial ... -
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
(PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ... -
Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis
(PLoS One. Vol.8, n.12 (2013), e81990, 2013-12)Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ... -
Subdiffraction localization of a nanostructured photosensitizer in bacterial cells
(Scientific Reports. Vol.5, 15564 (2015), 2015-10)Antibacterial treatments based on photosensitized production of reactive oxygen species is a promising approach to address local microbial infections. Given the small size of bacterial cells, identification ... -
Substrate distortion in the Michaelis complex of Bacillus 1,3–1,4-β-glucanase: insight from first principles molecular dynamics simulations
(Journal of Biological Chemistry. Vol.281, n.3 (2006), p.1432–1441, 2006-01)The structure and dynamics of the enzyme-substrate complex of Bacillus 1,3–1,4-β-glucanase, one of the most active glycoside hydrolases, is investigated by means of Car-Parrinello molecular dynamics ... -
Synthesis, photophysical characterization and photoinduced antibacterial activity of methylene blue-loaded amino- and mannose-targeted mesoporous silica nanoparticles
(Molecules. Vol.20, n.4 (2015), p.6284-6298, 2015-04)Over the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial ...