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Thermodynamic Characterization of Gas Mixtures for Non-Thermal Plasma CO2 Conversion Applications with Soft-SAFT
(Journal of Chemical & Engineering Data 2023, 68, 1376-1387, 2023-06-08)Carbon dioxide (CO2) transformation into added-value products through non-thermal plasma (NTP) represents a novel technology of interest. The process involves, apart from CO2, mixtures of different gases ... -
Neuronal Prosurvival Role of Ceramide Synthase 2 by Olidogendrocyte-to-Neuron Extracellular Vesicle Transfer
(International Journal of Molecular Sciences 2023, 24(6), 5986, 2023-03)Ageing is associated with notorious alterations in neurons, i.e., in gene expression, mitochondrial function, membrane degradation or intercellular communication. However, neurons live for the entire ... -
In Vitro Antibacterial Activity of Silver Nanoparticles Conjugated with Amikacin and Combined with Hyperthermia against Drug-Resistant and Biofilm-Producing Strains
(Microbiology Spectrum 2023, 11 (3), 2023-06)In view of the current increase and spread of antimicrobial resistance (AMR), there is an urgent need to find new strategies to combat it. This study had two aims. First, we synthesized highly monodispersed ... -
Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells
(The Journal of Organic Chemistry 2023, 88, 7128-7140, 2023-06-02)Releasing bioactive molecules in specific subcellular locations from the corresponding caged precursors offers great potential in photopharmacology, especially when using biologically compatible visible ... -
NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging
(Sensors 2023, 23(10), 4603, 2023-05)An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan ... -
De-Novo Design of pre-miR-21 Maturation Inhibitors: Synthesis and Activity Assessment
(Chemistry - A European Journal 2023, 29(40),e202300825, 2023-07-14)Targeting RNA with small molecules is a major challenge of current medicinal chemistry, and the identification and design of original scaffolds able to selectively interact with an RNA target remains ... -
Biomineralization in Three-Dimensional Scaffolds Based on Bacterial Nanocellulose for Bone Tissue Engineering: Feature Characterization and Stem Cell Differentiation
(Polymers 2023, 15(9), 2012, 2023-05)Bacterial nanocellulose (BNC) has a negative surface charge in physiological environments, which allows the adsorption of calcium ions to initiate the nucleation of different calcium phosphate phases. ... -
Poly(β-amino ester)s-Based Delivery Systems for Targeted Transdermal Vaccination
(Pharmaceutics 2023, 15(4), 1262, 2023-04)Nucleic acid vaccines have become a transformative technology to fight emerging infectious diseases and cancer. Delivery of such via the transdermal route could boost their efficacy given the complex ... -
Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
(Life Science Alliance 2023, 6 (6), e202201789, 2023-06)In this work, we tested the hypothesis that the development of dementia in individuals with type 2 diabetes (T2DM) requires a genetic background of predisposition to neurodegenerative disease. As a proof ... -
Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage
(Biomaterials Science 2023, 13 (10), 2023-05)Auricular reconstruction in children with microtia is one of the more complex procedures in plastic surgery. Obtaining sufficient native material to build an ear requires harvesting large fragments of ... -
Overview of the current situation relating to chemical engineering degree courses
(Education for Chemical Engineers 2023, 43, 2023-04)In 2020, the Conference of Chemical Engineering Directors and Deans (CODDIQ) proposed the creation of an observatory to monitor chemical engineering degrees in Spain. This representative radiography of ... -
Nucleic acid-loaded poly(beta-aminoester) nanoparticles for cancer nano-immuno therapeutics
(Drug Delivery and Translational Research. 2024;14:3477–3493, 2024-05-03)Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients’ quality of life. However, realizing the full potential of immunotherapy in ... -
Environmental performance and firm performance in Europe
(Corporate Social Responsibility and Environmental Management. 2024;31(6):5109-6525, 2024-07-01)This research presents novel insights into the relationship between environmental performance and firm performance, focusing on the moderating role of board governance. Unlike the single-dimensional ... -
Hybrid analytical surrogate-based process optimization via Bayesian symbolic regression
(Computers & Chemical Engineering. 2024;182:108563, 2024-01-09)Modular chemical process simulators are widespread in chemical industries to design and optimize production processes with sufficient accuracy. However, convergence issues and entrapment in local optima ... -
Algebraic surrogate-based flexibility analysis of process units with complicating process constraints
(Computers & Chemical Engineering. 2024;184:108630, 2024-03-11)Flexibility analyses are widespread in chemical engineering to quantify allowed deviations from nominal conditions. Standard approaches to perform flexibility analysis can be hard to apply if process ... -
Comparison of two peroxidases with high potential for biotechnology applications – HRP vs. APEX2
(Computational and structural biotechnology journal. 2024,23:742-751, 2024-01-12)Peroxidases are essential elements in many biotechnological applications. An especially interesting concept involves split enzymes, where the enzyme is separated into two smaller and inactive proteins ... -
High-Compression Crash Simulations and Tests of PLA Cubes Fabricated Using Additive Manufacturing FDM with a Scaling Strategy
(Computation. 2024;12(3):40, 2024-02-23)Impacts due to drops or crashes between moving vehicles necessitate the search for energy absorption elements to prevent damage to the transported goods or individuals. To ensure safety, a given level ... -
A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions
(Chemical Space 2023, 15(26), 2023-07-14)Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially ... -
Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates
(Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ... -
Cyclic Homo- and Heterohalogen Di-λ3-diarylhalonium Structures
(Journal of the American Chemical Society 2023, 145 (25), 13796–13804, 2023-06-28)In the context of the ever-growing interest in the cyclic diaryliodonium salts, this work presents synthetic design principles for a new family of structures with two hypervalent halogens in the ring. ...