Carminic acid linked to silica nanoparticles as pigment/antioxidant bifunctional excipient for pharmaceutical emulsions
Author
Nonell, Santi
Morales, Javier
Arriagada, Francisco
Ugarte, Catalina
Günther, Germán
Larraín, María Angélica
Guarnizo-Herrero, Víctor
Other authors
Universitat Ramon Llull. IQS
Publication date
2020-04Abstract
The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant capacity of the materials, has been of great interest to the pharmaceutical, chemical and food industries. The aim of this work was to prepare and characterize a bifunctional pigment–antioxidant nanomaterial-based carminic acid-decorated solid core-mesoporous shell silica nanoparticles, evaluating its properties as a pigment, its antioxidant capacity and its properties as a chemical stabilizer of emulsions. The chemical stability of oil-in-water (O/W) Pickering emulsions was evaluated determining the stability of vitamin E solubilized in the oil phase. Carminic acid was attached through the action of coupling ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) agents, and the resulting spherical and homogeneous nanoparticles showed a diameter close to 175 nm. A notorious change of emulsion color was observed by the addition of the nanomaterial. Emulsions showed an attractive pink color, and when the pH was adjusted to pH 3 and pH 9, a change in color was observed, analogous to carminic acid in solution. The nanomaterial incorporation also improved chemical stability, decreasing vitamin E consumption to 9.26% of the initial value, demonstrating an important antioxidant effect of the developed nanomaterial.
Document Type
Article
Published version
Language
English
Subject (CDU)
54 - Chemistry. Crystallography. Mineralogy
615 - Pharmacology. Therapeutics. Toxicology
Keywords
Àcids
Antioxidants
Carminic acid
Emulsion
Antioxidant
Silica nanoparticles
Nanoexcipients
Pages
17 p.
Publisher
MDPI
Is part of
Pharmaceutics. Vol.12, n.4 (2020), 376
Grant agreement number
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-R
info:eu-repo/grantAgreement/CONICYT/FONDECYT/1160757
info:eu-repo/grantAgreement/CONICYT/CONICYT/2116093
info:eu-repo/grantAgreement/Universidad de Chile/PII2019
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/