Browsing by Author "Nonell, Santi"
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9-Aryl-phenalenones: Bioinspired thermally reversible photochromic compounds for photoswitching applications in the pico-to milliseconds range
Bresolí-Obach, Roger; Massad, Walter; Abudulimu, Abasi; Lüer, Larry; Flors, Cristina; Luis, Javier G.; Rosquete, Laura I.; Abad- Grillo, Teresa; Anamimoghadam, Ommid; Bucher, Götz; Nonell, Santi (Dyes and Pigments 2021, 186, 2021-02)Ultrafast photochromic molecules are being actively investigated to meet the demand for fast optical switching systems. Inspired on the irreversible cyclization of 9-phenylphenalenone plant metabolites ... -
A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
Nonell, Santi; Agut, Montserrat; Ruiz González, Rubén; Reddi, Elena (International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ... -
A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein
Rodríguez Amigo, Beatriz; Hally, Cormac; Roig Yanovsky, Núria; Delcanale, Pietro; Abbruzzetti, Stefania; Agut, Montserrat; Viappiani, Cristiano; Nonell, Santi (Antibiotics, 11(2), 2022, 282, 2022)Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques ... -
A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions
Ortega Forte, Enrique; Rovira, Anna; López Corrales, Marta; Hernández García, Alba; Ballester, Francisco José; Izquierdo García, Eduardo; Jordà Redondo, Mireia; Bosch, Manel; Nonell, Santi; Santana, María Dolores; Ruiz, José; Marchán, Vicente; Gasser, Gilles (Chemical Space 2023, 15(26), 2023-07-14)Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially ... -
A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents
Nonell, Santi; Planas, Oriol; Gallavardin, Thibault (Chemical Communications. Vol.51, n.26 (2015), p.5586-5589, 2014-12)Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The ... -
Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)–COUPY conjugates
Ortega-Forte, Enrique; Rovira, Anna; Ashoo, Pezhman; Izquierdo García, Eduardo; Hally, Cormac; Abad-Montero, Diego; Jordà Redondo, Mireia; Vigueras Bautista, Gloria; Deyà, Alba; Hernández, José Luis; GALINO, JORGE; Bosch, Manel; Alberto, Marta Erminia; Francés-Monerris, Antonio; Nonell, Santi; Ruiz, Jose; Marchán, Vicente (Inorganic Chemistry Frontiers 2023, 12 (9), 2025-05-07)Despite the potential of photodynamic therapy (PDT), this oxygen-dependent oncological treatment is greatly restricted in the clinic by the well-known hypoxic feature of solid tumors. Here we provide ... -
An antibody-photosensitiser bioconjugate overcomes trastuzumab resistance in HER2-positive breast cancer
Jordà Redondo, Mireia; Piqueras, Ana; Castillo, Ana; Fernandez, Pedro Luis; Bresolí Obach, Roger; Blay, Lidia; Julian Ibañez, Joan Francesc; Nonell, Santi (European Journal of Medicinal Chemistry 2025, 290, 2025-06-05)HER2-positive breast cancer, characterized by the overexpression of HER2 receptors, often develops resistance to trastuzumab, limiting its therapeutic efficacy. In this study, we explore the use of ... -
An Ultra-Long-Lived Triplet Excited State in Water at Room Temperature: Insights on the Molecular Design of Tridecafullerenes
Ramos-Soriano, Javier; Pérez-Sánchez, Alfonso; Ramírez-Barroso, Sergio; Beatriz, Illescas; Rodriguez-Fortea, Antonio; Poblet, Josep M.; Hally, Cormac; Nonell, Santi; García-Fresnadillo, David; Rojo, Javier; Martín, Nazario; Azmani, Khalid (Angewandte Chemie International Edition, 2021-05-13)Suitably engineered molecular systems exhibiting triplet excited states with very long lifetimes are important for high-end applications in nonlinear optics, photocatalysis, or biomedicine. We report ... -
Antimicrobial efficacy of solar disinfection in cellulose fiber supported photoactive materials
Langerreiter, Daniel; Solin, Katariina; Jordà Redondo, Mireia; Bresolí Obach, Roger; Fliri, Lukas; Nonell, Santi; Kostiainen, Mauri A.; Anaya-Plaza, Eduardo (Materials Today Communications. 2024;38:107858, 2023-12-29)According to the World Health Organization, antimicrobial resistance is one of the emerging threats to global health. Therefore, the development of new strategies to mitigate resistant bacterial strains ... -
Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer
Nonell, Santi; Juarranz, Ángeles; De la Torre, Gema; Torres, Tomás; Revuelta-Maza, Miguel Á.; Mascaraque, Marta; González-Jiménez, Patricia; González-Camuñas, Arturo (Molecules. Vol.25, n.1 (2020), 213, 2020-01)We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ... -
Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy
Nonell, Santi; Ruiz González, Rubén; Torra, Joaquim; Rodríguez-Pulido, Alberto; Cortajarena, Aitziber L.; Flors, Cristina (Chemical Communications. Vol.52, n.54 (2016), p.8405-8408, 2016-06)Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the photostability of miniSOG mutants and their ability to photooxidize ... -
Bactericidal effect of photodynamic therapy, alone or in combination with mupirocin or linezolid, on Staphylococcus aureus
Nonell, Santi; Pérez-Laguna, Vanesa; Pérez-Artiaga, Luna; Lampaya-Pérez, Verónica; García-Luque, Isabel; Ballesta, Sofía; Paz-Cristobal, Manuel P.; Gilaberte, Yolanda; Rezusta, Antonio (Frontiers in Microbiology. Vol. 8 (2017), 1002, 2017-05)Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an ... -
Carminic acid linked to silica nanoparticles as pigment/antioxidant bifunctional excipient for pharmaceutical emulsions
Nonell, Santi; Morales, Javier; Arriagada, Francisco; Ugarte, Catalina; Günther, Germán; Larraín, María Angélica; Guarnizo-Herrero, Víctor (Pharmaceutics. Vol.12, n.4 (2020), 376, 2020-04)The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant ... -
Cluster and Kill: the Use of Clustering-Triggered Emission Materials for Singlet Oxygen Photosensitization in Antimicrobial Photodynamic Therapy
Dueñas Parro, Karina; Gulias, Oscar; Agut, Montserrat; de la Cruz-Martínez, Felipe; Lara Sánchez, Agustín; Castro Osma, José A.; García Reyes, Juan F.; Sánchez Ruiz, Antonio; Martín, Cristina; Nonell, Santi; Bresolí Obach, Roger (Advanced Optical Materials 2025, 13 (3), 2402179, 2025-01-24)The emergence of light-based technologies is revolutionizing modern medicine and healthcare by enabling precise disease diagnosis and treatment through various luminescent agents and imaging techniques. ... -
Concanavalin A Delivers a Photoactive Protein to the Bacterial Wall
Mussini, Andrea; Delcanale, Pietro; Berni, Melissa; Pongolini, Stefano; Agut, Montserrat; Steinbach, Peter J.; Nonell, Santi; Abbruzzetti, Stefania; Viappiani, Cristiano (International Journal of Molecular Sciences. 2024;25(11):5751, 2024-05-25)Modular supramolecular complexes, where different proteins are assembled to gather targeting capability and photofunctional properties within the same structures, are of special interest for bacterial ... -
Development of green/red-absorbing chromophores based on a coumarin scaffold that are useful as caging groups
Nonell, Santi; Gandioso, Albert; Contreras, Sara; Melnyk, Ivanna; Oliva, Javier; Velasco Castrillo, Dolores; Garcia Amorós, Jaume; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.82, n.10 (2017), p.5398-5408, 2017-05)We report the design, synthesis, and spectroscopic characterization of a series of push–pull chromophores based on a novel coumarin scaffold in which the carbonyl of the lactone function of the original ... -
Do folate-receptor targeted liposomal photosensitizers enhance photodynamic therapy selectivity?
Nonell, Santi; García Díaz, María; Sagristá, M. Lluïsa; Villanueva, Ángeles; Stockert, Juan Carlos; Cañete, Magdalena; Casadó, Ana; Mora, Margarita (Biochimica et Biophysica Acta (BBA) -Biomembranes. Vol.1808, n.4 (2011), p.1063-1071, 2011-01)One of the current goals in photodynamic therapy research is to enhance the selective targeting of tumor cells in order to minimize the risk and the extension of unwanted side-effects caused by normal ... -
Dual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effect
Lazaro Carrillo, Ana; Rodríguez Amigo, Beatriz; Mora, Margarita; Sagristá, M. Lluïsa; Cañete, Magdalena; Nonell, Santi; Villanueva, Ángeles (International Journal of Molecular Sciences, 23(21), 2022, 12817, 2022)The enhancement of photodynamic therapy (PDT) effectiveness by combining it with other treatment modalities and improved drug delivery has become an interesting field in cancer research. We have prepared ... -
Effective photodynamic inactivation of 26 Escherichia coli strains with different antibiotic susceptibility profiles: a planktonic and biofilm study
Nonell, Santi; Agut, Montserrat; Gulías Borau, Òscar; McKenzie, Giselle; Bayó, Miquel (Antibiotics. Vol.9, n.3 (2020), 98, 2020-02)The emergence of multidrug-resistant bacteria is a growing problem and alternative therapies are being sought to effectively address this issue. The aim of this study is to assess a range of Escherichia ... -
Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates
Rovira, Anna; Ortega Forte, Enrique; Hally, Cormac; Jordà Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús I.; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchán, Vicente (Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ...