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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorSemino, Carlos
dc.contributor.authorRubí-Sans, Gerard
dc.contributor.authorRecha Sancho, Lourdes Georgina
dc.contributor.authorPérez-Amodio, Soledad
dc.contributor.authorMateos-Timoneda, Miguel Ángel
dc.contributor.authorEngel, Elisabeth
dc.date.accessioned2021-07-12T17:53:44Z
dc.date.accessioned2023-07-13T05:45:53Z
dc.date.available2021-07-12T17:53:44Z
dc.date.available2023-07-13T05:45:53Z
dc.date.issued2019-12
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1114
dc.description.abstractDegenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe pain, loss of mobility and consequently, a loss of quality of life. Current strategies in medicine are focused on the partial or total replacement of affected joints, physiotherapy and analgesics that do not address the underlying pathology. In an attempt to find an alternative therapy to restore or repair articular cartilage functions, the use of bioengineered tissues is proposed. In this study we present a three-dimensional (3D) bioengineered platform combining a 3D printed polycaprolactone (PCL) macrostructure with RAD16-I, a soft nanofibrous self-assembling peptide, as a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. This 3D bioengineered platform allows for long-term hMSC culture resulting in chondrogenic differentiation and has mechanical properties resembling native articular cartilage. These promising results suggest that this approach could be potentially used in articular cartilage repair and regeneration.eng
dc.format.extent19 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofBiomolecules. Vol.10, n.1 (2020), 52cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherBiologia--Aparells i instrumentscat
dc.subject.otherAutoassemblatgecat
dc.subject.otherCondrogènesicat
dc.subject.otherPolycaprolactonecat
dc.subject.other3D printingcat
dc.subject.otherRAD16-I self-assembling peptidecat
dc.subject.otherChondrogenic differentiationcat
dc.titleDevelopment of a three-dimensional bioengineered platform for articular cartilage regenerationcat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc57
dc.subject.udc61
dc.subject.udc62
dc.identifier.doihttps://doi.org/10.3390/biom10010052cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/MAT2015-68906-Rcat


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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