Development of a three-dimensional bioengineered platform for articular cartilage regeneration
Author
Semino, Carlos
Recha Sancho, Lourdes Georgina
Pérez-Amodio, Soledad
Mateos-Timoneda, Miguel Ángel
Engel, Elisabeth
Other authors
Universitat Ramon Llull. IQS
Publication date
2019-12Abstract
Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe pain, loss of mobility and consequently, a loss of quality of life. Current strategies in medicine are focused on the partial or total replacement of affected joints, physiotherapy and analgesics that do not address the underlying pathology. In an attempt to find an alternative therapy to restore or repair articular cartilage functions, the use of bioengineered tissues is proposed. In this study we present a three-dimensional (3D) bioengineered platform combining a 3D printed polycaprolactone (PCL) macrostructure with RAD16-I, a soft nanofibrous self-assembling peptide, as a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. This 3D bioengineered platform allows for long-term hMSC culture resulting in chondrogenic differentiation and has mechanical properties resembling native articular cartilage. These promising results suggest that this approach could be potentially used in articular cartilage repair and regeneration.
Document Type
Article
Published version
Language
English
Subject (CDU)
57 - Biological sciences in general
61 - Medical sciences
62 - Engineering. Technology in general
Keywords
Biologia--Aparells i instruments
Autoassemblatge
Condrogènesi
Polycaprolactone
3D printing
RAD16-I self-assembling peptide
Chondrogenic differentiation
Pages
19 p.
Publisher
MDPI
Is part of
Biomolecules. Vol.10, n.1 (2020), 52
Grant agreement number
info:eu-repo/grantAgreement/MINECO/PN I+D/MAT2015-68906-R
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/