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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorMartorell López, Jordi
dc.contributor.authorMolins Vara, José Javier
dc.contributor.authorPons, R.
dc.contributor.authorGuala, A.
dc.contributor.authorRodríguez-Palomares, J.F.
dc.contributor.authorCajas, J.C.
dc.contributor.authorDux-Santoy, L.
dc.contributor.authorTeixidó-Tura, G.
dc.contributor.authorVázquez, M.
dc.contributor.authorEvangelista, A.
dc.date.accessioned2021-07-25T17:08:40Z
dc.date.accessioned2023-07-13T05:45:40Z
dc.date.available2021-07-25T17:08:40Z
dc.date.available2023-07-13T05:45:40Z
dc.date.issued2020-02
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1105
dc.description.abstractAbnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid–structure interaction (FSI) simulations against four-dimensional (4D) flow magnetic resonance imaging (MRI) data; and to assess the capacity of advanced fluid dynamics markers to stratify aneurysm progression risk. Eight Marfan syndrome (MFS) patients, four with stable and four with dilating aneurysms of the proximal aorta, and four healthy controls were studied. FSI and CFD simulations were performed with MRI-derived geometry, inlet velocity field and Young's modulus. Flow displacement, jet angle and maximum velocity evaluated from FSI and CFD simulations were compared to 4D flow MRI data. A dimensionless parameter, the shear stress ratio (SSR), was evaluated from FSI and CFD simulations and assessed as potential correlate of aneurysm progression. FSI simulations successfully matched MRI data regarding descending to ascending aorta flow rates (R2 = 0.92) and pulse wave velocity (R2 = 0.99). Compared to CFD, FSI simulations showed significantly lower percentage errors in ascending and descending aorta in flow displacement (−46% ascending, −41% descending), jet angle (−28% ascending, −50% descending) and maximum velocity (−37% ascending, −34% descending) with respect to 4D flow MRI. FSI- but not CFD-derived SSR differentiated between stable and dilating MFS patients. Fluid dynamic simulations of the thoracic aorta require fluid–solid interaction to properly reproduce complex haemodynamics. FSI- but not CFD-derived SSR could help stratifying MFS patients.eng
dc.format.extent13 p.
dc.language.isoeng
dc.publisherThe Royal Society; Royal Society of Chemistry
dc.relation.ispartofRoyal Society Open Science. Vol.7, n.2 (2020), 191752
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherAneurismes aòrtics
dc.subject.otherBiologia computacional
dc.subject.otherDinàmica de fluids--Informàtica
dc.subject.otherInteracció fluid-estructura
dc.subject.otherAscending aorta aneurysm
dc.subject.otherMarfan syndrome
dc.subject.otherComputational fluid dynamic
dc.subject.otherFluid–structure interaction
dc.subject.otherShear stress ratio
dc.titleFluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscap
dc.subject.udc54
dc.identifier.doihttps://doi.org/10.1098/rsos.191752
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/RTC-2016-5152-1
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundació la Marató de TV3/grant no. 20151330
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-MCA/grant no. 267128
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PI14/0106
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ISCIII/PI17/00381
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant agreement ID:823712
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant agreement ID:777204


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Attribution 4.0 International
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