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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorAgut Bonsfills, Montserrat
dc.contributor.authorRuiz González, Rubén
dc.contributor.authorReddi, Elena
dc.date.accessioned2020-07-23T12:20:47Z
dc.date.accessioned2023-07-13T05:43:51Z
dc.date.available2020-07-23T12:20:47Z
dc.date.available2023-07-13T05:43:51Z
dc.date.issued2015-11
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1001
dc.description.abstractOver the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of bindingeng
dc.format.extent15 p.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherFotosensibilització (Biologia)
dc.subject.otherCitometria de fluxe
dc.subject.otherFotoquimioteràpia
dc.subject.otherPhotodynamic therapy
dc.subject.otherAntimicrobial photoinactivation
dc.subject.otherMRSA
dc.subject.otherP. aeruginosa
dc.subject.otherPhotosensitizer
dc.subject.otherPorphycenes
dc.subject.otherFlow cytometry
dc.subject.otherSinglet oxygen
dc.titleA comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscap
dc.subject.udc577
dc.identifier.doihttps://doi.org/10.3390/ijms161125999
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/IT2009-003


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Attribution 4.0 International
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