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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorAgut Bonsfills, Montserrat
dc.contributor.authorRagàs Amalrich, Xavier
dc.contributor.authorHe, Xin
dc.contributor.authorRoxo-Rosa, Mónica
dc.contributor.authorRocha Gonsalves, António
dc.contributor.authorSerra, Arménio C.
dc.date.accessioned2020-10-26T16:32:11Z
dc.date.accessioned2023-07-13T05:43:48Z
dc.date.available2020-10-26T16:32:11Z
dc.date.available2023-07-13T05:43:48Z
dc.date.issued2013-02
dc.identifier.urihttp://hdl.handle.net/20.500.14342/994
dc.description.abstractSeveral families of photosensitizers are currently being scrutinized for antimicrobial photodynamic therapy applications. Differences in physical and photochemical properties can lead to different localization patterns as well as differences in singlet oxygen production and decay when the photosensitizers are taken up by bacterial cells. We have examined the production and fate of singlet oxygen in Escherichia coli upon photosensitization with three structurally-different cationic photosensitizers, namely New Methylene Blue N (NMB), a member of the phenothiazine family, ACS268, a hydrophobic porphyrin with a single cationic alkyl chain, and zinc(II)-tetramethyltetrapyridinoporphyrazinium salt, a phthalocyanine-like photosensitizer with four positive charges on the macrocycle core. The kinetics of singlet oxygen production and decay indicate different localization for the three photosensitizers, whereby NMB appears to localize in an aqueous-like microenvironment, whereas ACS268 localizes in an oxygen-shielded site, highly reactive towards singlet oxygen. The tetracationic zinc(II) tetrapyridinoporphyrazine is extensively aggregated in the bacteria and fails to produce any detectable singlet oxygen.eng
dc.format.extent14 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofMolecules. Vol.18, n.3 (2013), p.2712-2725cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherFotoquimioteràpiacat
dc.subject.otherAnàlisi espectralcat
dc.subject.otherEscheríchia colicat
dc.subject.otherAntimicrobial photodynamic therapycat
dc.subject.otherCationic photosensitizerscat
dc.subject.otherE. colicat
dc.subject.otherKineticscat
dc.subject.otherPhotodynamic inactivationcat
dc.subject.otherSinglet oxygencat
dc.subject.otherTime-resolved near-IR spectroscopycat
dc.titleSinglet oxygen in antimicrobial photodynamic therapy: photosensitizer-dependent production and decay in E. colicat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc577
dc.identifier.doihttps://doi.org/10.3390/molecules18032712cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/ CTQ2007-67763-C03-01/BQUcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2010-20870-C03-01cat


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Attribution 4.0 International
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