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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorBresolí Obach, Roger
dc.contributor.authorFont Inglès, Joan
dc.contributor.authorLópez-Cano, Marc
dc.contributor.authorNotartomaso, Serena
dc.contributor.authorScarselli, Pamela
dc.contributor.authorDi Pietro, Paola
dc.contributor.authorBattaglia, Giuseppe
dc.contributor.authorMalhaire, Fanny
dc.contributor.authorRovira, Xavier
dc.contributor.authorCatena, Juanlo
dc.contributor.authorGiraldo, Jesús
dc.contributor.authorPin, Jean-Philippe
dc.contributor.authorFernández-Dueñas, Víctor
dc.contributor.authorGoudet, Cyril
dc.contributor.authorNicoletti, Ferdinando
dc.contributor.authorLlebaria, Amadeu
dc.contributor.authorCiruela, Francisco
dc.date.accessioned2020-10-26T16:57:09Z
dc.date.accessioned2023-07-13T05:43:47Z
dc.date.available2020-10-26T16:57:09Z
dc.date.available2023-07-13T05:43:47Z
dc.date.issued2017-04
dc.identifier.urihttp://hdl.handle.net/20.500.14342/993
dc.description.abstractLight-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator raseglurant. Violet light illumination of JF-NP-26 induces a photochemical reaction prompting the active-drug’s release, which effectively controls mGlu5 receptor activity both in ectopic expressing systems and in striatal primary neurons. Systemic administration in mice followed by local light-emitting diode (LED)-based illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflammatory pain models. These data offer the first example of optical control of analgesia in vivo using a photocaged mGlu5 receptor negative allosteric modulator. This approach shows potential for precisely targeting, in time and space, endogenous receptors, which may allow a better management of difficult-to-treat disorders.eng
dc.format.extent20 p.cat
dc.language.isoengcat
dc.publishereLife Sciences Publicationscat
dc.relation.ispartofeLIFE. Vol.6 (2017), e23545cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherDolor--Tractamentcat
dc.subject.otherAnalgèsiacat
dc.subject.otherMalalties cròniquescat
dc.subject.otherLight-operated drugscat
dc.subject.otherComplex diseasescat
dc.subject.otherOptical controlcat
dc.titleOptical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulatorcat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc615
dc.identifier.doihttps://doi.org/10.7554/elife.23545cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO I ISCIII /PN I+D/SAF2014-55700-Pcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO I ISCIII /PN I+D/PCIN-2013–019 C03-03cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO I ISCIII/PN I+D/PIE14/00034cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2014-SGR-1054cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/ICREA/ICREA Academia-2010cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundació La Marató TV3/20152031cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/IWT/SBO-140028cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/PCIN-2013–018 C03-02cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/SAF2014-58396-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/PCIN-2013–017 C03-01cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2014-57020-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/2014CTP0002cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2015-71896-REDTcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2014-SGR-109cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2014-SGR-304cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2016 FI_B1 00021cat


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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