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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorPlanas Marquès, Oriol
dc.contributor.authorBresolí Obach, Roger
dc.contributor.authorNos, Jaume
dc.contributor.authorGallavardin, Thibault
dc.contributor.authorRuiz González, Rubén
dc.contributor.authorAgut Bonsfills, Montserrat
dc.contributor.authorNonell, Santi
dc.date.accessioned2020-11-19T12:57:37Z
dc.date.accessioned2023-07-13T05:43:44Z
dc.date.available2020-11-19T12:57:37Z
dc.date.available2023-07-13T05:43:44Z
dc.date.issued2015-04
dc.identifier.urihttp://hdl.handle.net/20.500.14342/989
dc.description.abstractOver the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. We have explored the effectiveness of methylene blue-loaded targeted mesoporous silica nanoparticles (MSNP) in the photodynamic inactivation of two Gram negative bacteria, namely Escherichia coli and Pseudomonas aeruginosa. For E. coli, nanoparticle association clearly reduced the dark toxicity of MB while preserving its photoinactivation activity. For P. aeruginosa, a remarkable difference was observed between amino- and mannose-decorated nanoparticles. The details of singlet oxygen production in the nanoparticles have been characterized, revealing the presence of two populations of this cytotoxic species. Strong quenching of singlet oxygen within the nanoparticles is observed.eng
dc.format.extent15 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofMolecules. Vol.20, n.4 (2015), p.6284-6298cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherFotoquimioteràpiacat
dc.subject.otherMedicaments--Modes d'administraciócat
dc.subject.otherEscheríchia colicat
dc.subject.otherAntimicrobial photodynamic therapycat
dc.subject.otherSinglet oxygencat
dc.subject.otherMesoporous silica nanoparticle (MSNP)cat
dc.subject.otherMethylene bluecat
dc.subject.otherDrug delivery systemcat
dc.subject.otherMannosecat
dc.subject.otherE. colicat
dc.subject.otherP. aeruginosacat
dc.titleSynthesis, photophysical characterization and photoinduced antibacterial activity of methylene blue-loaded amino- and mannose-targeted mesoporous silica nanoparticlescat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc577
dc.identifier.doihttps://doi.org/10.3390/molecules20046284cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2015 FI_B1 00063cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2015 FI_B 00315cat


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