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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorMartorell López, Jordi
dc.contributor.authorPolcaro, Alessandro
dc.contributor.authorTroelstra, Marian Amber
dc.contributor.authorRunge, Jurgen Henk
dc.contributor.authorBurnhope, Emma
dc.contributor.authorGuenthner, Christian
dc.contributor.authorSchneider, Torben
dc.contributor.authorRazavi, Reza
dc.contributor.authorIsmail, Tevfik F.
dc.contributor.authorSinkus, Ralph
dc.date.accessioned2021-01-18T13:08:37Z
dc.date.accessioned2023-07-13T05:43:32Z
dc.date.available2021-01-18T13:08:37Z
dc.date.available2023-07-13T05:43:32Z
dc.date.issued2021-01
dc.identifier.urihttp://hdl.handle.net/20.500.14342/972
dc.description.abstractChanges in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induced shear waves. Using motion-sensitized two-dimensional pencil beams, septal shear waves were imaged at high temporal resolution. Shear wave speed was measured using time-of-flight of waves travelling between two pencil beams and corrected for geometrical biases. After validation in phantoms, results from twelve healthy volunteers and five cardiac patients (two left ventricular hypertrophy, two myocardial infarcts, and one without confirmed pathology) were obtained. Torsional shear wave speed in the phantom was 3.0 ± 0.1 m/s, corresponding with reference speeds of 2.8 ± 0.1 m/s. Geometrically-biased flexural shear wave speed was 1.9 ± 0.1 m/s, corresponding with simulation values of 2.0 m/s. Corrected septal shear wave speeds were significantly higher in patients than healthy volunteers [14.1 (11.0–15.8) m/s versus 3.6 (2.7–4.3) m/s, p = 0.001]. The interobserver 95%-limits-of-agreement in healthy volunteers were ± 1.3 m/s and interstudy 95%-limits-of-agreement − 0.7 to 1.2 m/s. In conclusion, myocardial shear wave speed can be measured using aortic valve closure-induced shear waves, with cardiac patients showing significantly higher shear wave speeds than healthy volunteers. This non-invasive measure may provide valuable insights into the pathophysiology of heart failure.eng
dc.format.extent14 p.cat
dc.language.isoengcat
dc.publisherNature Researchcat
dc.relation.ispartofScientific Reports. Vol.11, 1403 (2021)cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherCardiologiacat
dc.subject.otherMiocardicat
dc.subject.otherTransductorscat
dc.subject.otherCardiologycat
dc.subject.otherCardiovascular diseasescat
dc.subject.otherMagnetic resonance imagingcat
dc.subject.otherTranslational researchcat
dc.titleShear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocitycat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc616.1
dc.identifier.doihttps://doi.org/10.1038/s41598-020-79231-zcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/Grant No. 668039cat


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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