Listando Recerca por materia "577"

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    • A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation 

      Nonell, Santi; Agut Bonsfills, Montserrat; Ruiz González, Rubén; Reddi, Elena (International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)
      Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ...

    • Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer 

      Nonell, Santi; Juarranz, Ángeles; De la Torre, Gema; Torres, Tomás; Revuelta-Maza, Miguel Á.; Mascaraque, Marta; González-Jiménez, Patricia; González-Camuñas, Arturo (Molecules. Vol.25, n.1 (2020), 213, 2020-01)
      We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ...

    • Charting the metabolic landscape of the facultative methylotroph bacillus methanolicus 

      Carnicer, Marc; Delépine, Baudoin; Gil López, Marina; Vicente, Cláudia M.; Wendisch, Volker F.; Heux, Stéphanie (Msystems. Vol.5, n.5 (2020), e00745-20, 2020-09)
      Bacillus methanolicus MGA3 is a thermotolerant and relatively fast-growing methylotroph able to secrete large quantities of glutamate and lysine. These natural characteristics make B. methanolicus a ...

    • Culture and differentiation of human hair follicle dermal papilla cells in a soft 3D self-assembling peptide scaffold 

      Semino, Carlos; Betriu, Nausika; Jarrosson-Moral, Claire (Biomolecules. Vol.10, n.5 (2020), 684, 2020-05)
      Hair follicle dermal papilla cells (HFDPC) are a specialized cell population located in the bulge of the hair follicle with unique characteristics such as aggregative behavior and the ability to induce ...

    • Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition 

      Wedekind, Roland; Rothwell, Joseph A.; Viallon, Vivian; Keski-Rahkonen, Pekka; Schmidt, Julie A.; Chajes, Veronique; Katzke, Vna; Johnson, Theron; Santucci de Magistris, Maria; Krogh, Vittorio; Amiano, Pilar; Sacerdote, Carlotta; Redondo-Sanchez, Daniel; Huerta, José María; Tjønneland, Anne; Pokharel, Pratik; Jakszyn, Paula; Tumino, Rosario; Ardanaz, Eva; Sandanger, Torkjel M.; Winkvist, Anna; Hultdin, Johan; Schulze, Matthias B.; Weiderpass, Elisabete; Gunter, Marc J.; Huybrechts, Inge; Scalbert, Augustin (Clinical nutrition, 2022, 41(8): 1735-1745, 2022-08)
      Background & aims Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to ...

    • Different mechanisms that promote protein monoubiquitination 

      Crosas, Bernat; Puig Sàrries, Pilar (Afinidad. Vol.72, n.570 (2015), p.95-100, 2015-04)
      Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity ...

    • Do folate-receptor targeted liposomal photosensitizers enhance photodynamic therapy selectivity? 

      Nonell, S. (Santi); García Díaz, María; Sagristá, M. Lluïsa; Villanueva, Ángeles; Stockert, Juan C.; Cañete, Magdalena; Casadó, Ana; Mora, Margarita (Biochimica et Biophysica Acta (BBA) -Biomembranes. Vol.1808, n.4 (2011), p.1063-1071, 2011-01)
      One of the current goals in photodynamic therapy research is to enhance the selective targeting of tumor cells in order to minimize the risk and the extension of unwanted side-effects caused by normal ...

    • Glycosidases and glycosynthases in enzymatic synthesis of oligosaccharides: an overview 

      Planas, Antoni (Planas Sauter); Faijes, Magda (Afinidad. Vol.59, n.500 (2002), p.295-313, 2002)
      Retaining glycosidases have been extensively studied for the synthesis of oligosaccharides and glycoconjugates as a convenient enzymatic approach to achieve the required regio- and stereoselectivity in ...

    • Nanoscale characterization coupled to multi-parametric optimization of Hi5 cell transient gene expression 

      Puente-Massaguer, Eduard; Lecina i Veciana, Martí; Gòdia, Francesc (Applied Microbiology and Biotechnology, 2018-10-13)
      Polyethylenimine (PEI)-based transient gene expression (TGE) is nowadays a well-established methodology for rapid protein production in mammalian cells, but it has been used to a much lower extent in ...

    • Octanol-water partition coefficients of highly hydrophobic photodynamic therapy drugs: a computational study 

      Estrada Tejedor, Roger; Sabaté, Noemí; Broto Puig, Francesc; Nonell, Santi (Afinidad. Vol.70, n.564 (2013), p.250-256, 2013-10)
      Photodynamic therapy is a novel treatment for solid tumors based on the selective induction of cell death by the generation of cytotoxic reactive oxygen species within neoplastic tissues. Oxygen ...

    • On the mechanism of Candida tropicalis biofilm reduction by the combined action of naturally-occurring anthraquinones and blue light 

      Nonell, Santi; Bresolí Obach, Roger; Agut Bonsfills, Montserrat; Marioni, Juliana; Comini, Laura R.; Cabrera, José L.; Paraje, María G.; Núñez Montoya, Susana C. (PLoS ONE. Vol.12, n.7 (2017), e0181517, 2017-07)
      The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of ...

    • Photosensitizing proteins for antibacterial photodynamic inactivation 

      Nonell, Santi; Hally Garcia, Cormac Elías; Delcanale, Pietro; Viappiani, Cristiano; Abbruzzetti, Stefania (Translational Biophotonics. Vol.2, n.1-2 (2020) e201900031, 2020-05)
      We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ...

    • Preparative scale production of recombinant human transthyretin for biophysical studies of protein-ligand and protein-protein interactions 

      Planas, Antoni (Planas Sauter); Arsequell, Gemma; Cotrina, Ellen Y.; Vilà, Marta; Nieto, Joan (International Journal of Molecular Sciences. Vol.21, n.24 (2020), 9640, 2020-12)
      Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial ...

    • Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue 

      Gonzalez-Franquesa, Alba; Gama Pérez, Pau; Kulis, Marta; Szczepanowska, Karolina; Dahdah, Norma; Moreno-Gomez, Sonia; Latorre-Pellicer, Ana; Fernández-Ruiz, Rebeca; Aguilar-Mogas, Antoni; Hoffman, Anne; Monelli, Erika; Samino, Sara; Miró-Blanch, Joan; Oemer, Gregor; Duran, Xavier; Sanchez-Rebordelo, Estrella; Schneeberger, Marc; Obach, Merce; Montane Mogas, Joel; Castellano, Giancarlo; Chapaprieta, Vicente; Sun, Wenfei; Navarro, Lourdes; Prieto, Ignacio; Castaño, Carlos; Novials, Anna; Gomis, Ramon; Monsalve, Maria; Claret, Marc; Graupera, Mariona; Soria, Guadalupe; Wolfrum, Christian; Vendrell, Joan; Fernández-Veledo, Sonia; Enríquez, José Antonio; Carracedo, Angel; Perales , José Carlos; Nogueiras, Ruben; Herrero, Laura; Trifunovic, Aleksandra; Keller, Markus A.; Yanes, Oscar; Sales-Pardo, Marta; Guimerà, Roger; Blüher, Matthias; Martín-Subero, José Ignacio; Garcia-Roves, Pablo M. (Redox Biology, 2022, 54: 102353, 2022-06)
      Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, ...

    • Singlet oxygen in antimicrobial photodynamic therapy: photosensitizer-dependent production and decay in E. coli 

      Nonell, Santi; Agut Bonsfills, Montserrat; Ragàs Amalrich, Xavier; He, Xin; Roxo-Rosa, Mónica; Rocha Gonsalves, António; Serra, Arménio C. (Molecules. Vol.18, n.3 (2013), p.2712-2725, 2013-02)
      Several families of photosensitizers are currently being scrutinized for antimicrobial photodynamic therapy applications. Differences in physical and photochemical properties can lead to different ...

    • Smooth muscle cells orchestrate the endothelial cell response to flow and injury 

      Balcells Camps, Mercedes; Martorell López, Jordi; Olivé, Carla; Santacana, Marina; Chitalia, Vipul; Cardoso, Angelo A.; Edelman, Elazer R. (Circulation. Vol.121, n.20 (2010), p.2192–2199, 2010-05)
      Background—Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial ...

    • Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases 

      Faijes, Magda; Val Cid, Cristina; Biarnés Fontal, Xevi; Planas, Antoni (Planas Sauter) (PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)
      Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ...

    • Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis 

      Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Romero, Javier (Romero García); Francisco, Carles (PLoS One. Vol.8, n.12 (2013), e81990, 2013-12)
      Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ...

    • Subdiffraction localization of a nanostructured photosensitizer in bacterial cells 

      Agut Bonsfills, Montserrat; Nonell, Santi; Delcanale, Pietro; Pennacchietti, Francesca; Maestrini, Giulio; Rodríguez Amigo, Beatriz; Bianchini, Paolo; Diaspro, Alberto; Iagatti, Alessandro; Patrizi, Barbara; Foggi, Paolo; Abbruzzetti, Stefania; Viappiani, Cristiano (Scientific Reports. Vol.5, 15564 (2015), 2015-10)
      Antibacterial treatments based on photosensitized production of reactive oxygen species is a promising approach to address local microbial infections. Given the small size of bacterial cells, identification ...

    • Substrate distortion in the Michaelis complex of Bacillus 1,3–1,4-β-glucanase: insight from first principles molecular dynamics simulations 

      Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Nieto, Joan; Rovira i Virgili, Carme (Journal of Biological Chemistry. Vol.281, n.3 (2006), p.1432–1441, 2006-01)
      The structure and dynamics of the enzyme-substrate complex of Bacillus 1,3–1,4-β-glucanase, one of the most active glycoside hydrolases, is investigated by means of Car-Parrinello molecular dynamics ...